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Total Synthesis of the Antimitotic Marine Macrolide (−)-Leiodermatolide**

Leiodermatolide is an antimitotic macrolide isolated from the marine sponge Leiodermatium sp. whose potentially novel tubulin-targeting mechanism of action makes it an exciting lead for anticancer drug discovery. In pursuit of a sustainable supply, we report a highly stereocontrolled total synthesis...

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Detalles Bibliográficos
Autores principales:	Paterson, Ian, Ng, Kenneth K-H, Williams, Simon, Millican, David C, Dalby, Stephen M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2014
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499261/ https://www.ncbi.nlm.nih.gov/pubmed/24481746 http://dx.doi.org/10.1002/anie.201310164

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