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MicroRNAs: Novel Players in Aortic Aneurysm
An aortic aneurysm (AA) is a common disease with potentially life-threatening complications. Despite significant improvements in the diagnosis and treatment of AA, the associated morbidity and mortality remain high. MicroRNAs (miRNAs, miR) are small noncoding ribonucleic acids that negatively regula...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499374/ https://www.ncbi.nlm.nih.gov/pubmed/26221607 http://dx.doi.org/10.1155/2015/831641 |
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author | Fu, Xian-ming Zhou, Yang-zhao Cheng, Zhao Liao, Xiao-bo Zhou, Xin-min |
author_facet | Fu, Xian-ming Zhou, Yang-zhao Cheng, Zhao Liao, Xiao-bo Zhou, Xin-min |
author_sort | Fu, Xian-ming |
collection | PubMed |
description | An aortic aneurysm (AA) is a common disease with potentially life-threatening complications. Despite significant improvements in the diagnosis and treatment of AA, the associated morbidity and mortality remain high. MicroRNAs (miRNAs, miR) are small noncoding ribonucleic acids that negatively regulate gene expression at the posttranscriptional level by inhibiting mRNA translation or promoting mRNA degradation. miRNAs are recently reported to be critical modulators for vascular cell functions such as cell migration, contraction, differentiation, proliferation, and apoptosis. Increasing evidences suggest crucial roles of miRNAs in the pathogenesis and progression of cardiovascular diseases such as coronary artery disease, heart failure, arterial hypertension, and cardiac arrhythmias. Recently, some miRNAs, such as miR-24, miR-155, miR-205, miR-712, miR-21, miR-26a, miR-143/145, miR-29, and miR-195, have been demonstrated to be differentially expressed in the diseased aortic tissues and strongly associated with the development of AA. In the present paper, we reviewed the recent available literature regarding the role of miRNAs in the pathogenesis of AA. Moreover, we discuss the potential use of miRNAs as diagnostic and prognostic biomarkers and novel targets for development of effective therapeutic strategies for AA. |
format | Online Article Text |
id | pubmed-4499374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44993742015-07-28 MicroRNAs: Novel Players in Aortic Aneurysm Fu, Xian-ming Zhou, Yang-zhao Cheng, Zhao Liao, Xiao-bo Zhou, Xin-min Biomed Res Int Review Article An aortic aneurysm (AA) is a common disease with potentially life-threatening complications. Despite significant improvements in the diagnosis and treatment of AA, the associated morbidity and mortality remain high. MicroRNAs (miRNAs, miR) are small noncoding ribonucleic acids that negatively regulate gene expression at the posttranscriptional level by inhibiting mRNA translation or promoting mRNA degradation. miRNAs are recently reported to be critical modulators for vascular cell functions such as cell migration, contraction, differentiation, proliferation, and apoptosis. Increasing evidences suggest crucial roles of miRNAs in the pathogenesis and progression of cardiovascular diseases such as coronary artery disease, heart failure, arterial hypertension, and cardiac arrhythmias. Recently, some miRNAs, such as miR-24, miR-155, miR-205, miR-712, miR-21, miR-26a, miR-143/145, miR-29, and miR-195, have been demonstrated to be differentially expressed in the diseased aortic tissues and strongly associated with the development of AA. In the present paper, we reviewed the recent available literature regarding the role of miRNAs in the pathogenesis of AA. Moreover, we discuss the potential use of miRNAs as diagnostic and prognostic biomarkers and novel targets for development of effective therapeutic strategies for AA. Hindawi Publishing Corporation 2015 2015-06-28 /pmc/articles/PMC4499374/ /pubmed/26221607 http://dx.doi.org/10.1155/2015/831641 Text en Copyright © 2015 Xian-ming Fu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fu, Xian-ming Zhou, Yang-zhao Cheng, Zhao Liao, Xiao-bo Zhou, Xin-min MicroRNAs: Novel Players in Aortic Aneurysm |
title | MicroRNAs: Novel Players in Aortic Aneurysm |
title_full | MicroRNAs: Novel Players in Aortic Aneurysm |
title_fullStr | MicroRNAs: Novel Players in Aortic Aneurysm |
title_full_unstemmed | MicroRNAs: Novel Players in Aortic Aneurysm |
title_short | MicroRNAs: Novel Players in Aortic Aneurysm |
title_sort | micrornas: novel players in aortic aneurysm |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499374/ https://www.ncbi.nlm.nih.gov/pubmed/26221607 http://dx.doi.org/10.1155/2015/831641 |
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