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Effects of Salvadora persica Extract on the Hematological and Biochemical Alterations against Immobilization-Induced Rats
A total of 24 rats were divided into 4 groups: control, stress, extract alone, and stress + extract (n = 6 each), for total 21 days of treatment. The immobilization stress was induced in rats by putting them in 20 cm × 7 cm plastic tubes for 2 h/day for 21 days. Rats were postorally treated with Sal...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499414/ https://www.ncbi.nlm.nih.gov/pubmed/26221565 http://dx.doi.org/10.1155/2015/253195 |
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author | Ramadan, Kholoud S. Alshamrani, Salha A. |
author_facet | Ramadan, Kholoud S. Alshamrani, Salha A. |
author_sort | Ramadan, Kholoud S. |
collection | PubMed |
description | A total of 24 rats were divided into 4 groups: control, stress, extract alone, and stress + extract (n = 6 each), for total 21 days of treatment. The immobilization stress was induced in rats by putting them in 20 cm × 7 cm plastic tubes for 2 h/day for 21 days. Rats were postorally treated with Salvadora persica at a dose of 900 mg/kg body weight via intragastric intubations. At the end of the test period, hematological and biochemical parameters were determined in blood and serum samples with determination of vital organs weights. The vital organ weights were not significantly affected in stressed rats as compared to control rats. Compared to the control group, the stress treated group showed significances in several hematological parameters, including decreases in WBC, RBC, and PLT counts. Furthermore, in comparison to the control group, the stress group showed significantly increased blood glucose, serum total cholesterol, LDL-cholesterol, and triacylglycerols levels and decreased HDL-cholesterol level. The hematological and biochemical parameters in the stress + extract treated group were approximately similar to control group. The SP extract restored the changes observed following stress treatment. |
format | Online Article Text |
id | pubmed-4499414 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44994142015-07-28 Effects of Salvadora persica Extract on the Hematological and Biochemical Alterations against Immobilization-Induced Rats Ramadan, Kholoud S. Alshamrani, Salha A. Scientifica (Cairo) Research Article A total of 24 rats were divided into 4 groups: control, stress, extract alone, and stress + extract (n = 6 each), for total 21 days of treatment. The immobilization stress was induced in rats by putting them in 20 cm × 7 cm plastic tubes for 2 h/day for 21 days. Rats were postorally treated with Salvadora persica at a dose of 900 mg/kg body weight via intragastric intubations. At the end of the test period, hematological and biochemical parameters were determined in blood and serum samples with determination of vital organs weights. The vital organ weights were not significantly affected in stressed rats as compared to control rats. Compared to the control group, the stress treated group showed significances in several hematological parameters, including decreases in WBC, RBC, and PLT counts. Furthermore, in comparison to the control group, the stress group showed significantly increased blood glucose, serum total cholesterol, LDL-cholesterol, and triacylglycerols levels and decreased HDL-cholesterol level. The hematological and biochemical parameters in the stress + extract treated group were approximately similar to control group. The SP extract restored the changes observed following stress treatment. Hindawi Publishing Corporation 2015 2015-06-28 /pmc/articles/PMC4499414/ /pubmed/26221565 http://dx.doi.org/10.1155/2015/253195 Text en Copyright © 2015 K. S. Ramadan and S. A. Alshamrani. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ramadan, Kholoud S. Alshamrani, Salha A. Effects of Salvadora persica Extract on the Hematological and Biochemical Alterations against Immobilization-Induced Rats |
title | Effects of Salvadora persica Extract on the Hematological and Biochemical Alterations against Immobilization-Induced Rats |
title_full | Effects of Salvadora persica Extract on the Hematological and Biochemical Alterations against Immobilization-Induced Rats |
title_fullStr | Effects of Salvadora persica Extract on the Hematological and Biochemical Alterations against Immobilization-Induced Rats |
title_full_unstemmed | Effects of Salvadora persica Extract on the Hematological and Biochemical Alterations against Immobilization-Induced Rats |
title_short | Effects of Salvadora persica Extract on the Hematological and Biochemical Alterations against Immobilization-Induced Rats |
title_sort | effects of salvadora persica extract on the hematological and biochemical alterations against immobilization-induced rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499414/ https://www.ncbi.nlm.nih.gov/pubmed/26221565 http://dx.doi.org/10.1155/2015/253195 |
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