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Calcium Channel Blockers, Progression to Dementia, and Effects on Amyloid Beta Peptide Production
Previous epidemiologic studies suggest that antihypertensive drugs may be protective against cognitive decline. To determine if subjects enrolled in the University of Kentucky longitudinal aging study who used antihypertensive drugs showed diminished progression to dementia, we used a 3-parameter lo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499419/ https://www.ncbi.nlm.nih.gov/pubmed/26221415 http://dx.doi.org/10.1155/2015/787805 |
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author | Lovell, Mark A. Abner, Erin Kryscio, Richard Xu, Liou Fister, Shuling X. Lynn, Bert C. |
author_facet | Lovell, Mark A. Abner, Erin Kryscio, Richard Xu, Liou Fister, Shuling X. Lynn, Bert C. |
author_sort | Lovell, Mark A. |
collection | PubMed |
description | Previous epidemiologic studies suggest that antihypertensive drugs may be protective against cognitive decline. To determine if subjects enrolled in the University of Kentucky longitudinal aging study who used antihypertensive drugs showed diminished progression to dementia, we used a 3-parameter logistic regression model to compare the rate of progression to dementia for subjects who used any of the five common categories of antihypertensive drugs to those with similar demographic characteristics but who did not use antihypertensives. Regression modeling showed that subjects who used calcium channel blockers (CCBs) but not the other classes of antihypertensives showed a significant decrease in the rate of progression to dementia. Significantly, use of CCBs ameliorated the negative effects of the presence of APOE-4 alleles on cognitive decline. To determine if CCBs could minimize amyloid beta peptide (Aβ (1–42)) production, H4 neuroglioma cultures transfected to overexpress APP were treated with various CCBs and Aβ (1–42) levels and levels of proteins involved in Aβ production were quantified. Results show that treatment with nifedipine led to a significant decrease in levels of Aβ (1–42), with no significant decrease in cell viability. Collectively, these data suggest that use of CCBs significantly diminishes the rate of progression to dementia and may minimize formation of Aβ (1–42). |
format | Online Article Text |
id | pubmed-4499419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44994192015-07-28 Calcium Channel Blockers, Progression to Dementia, and Effects on Amyloid Beta Peptide Production Lovell, Mark A. Abner, Erin Kryscio, Richard Xu, Liou Fister, Shuling X. Lynn, Bert C. Oxid Med Cell Longev Research Article Previous epidemiologic studies suggest that antihypertensive drugs may be protective against cognitive decline. To determine if subjects enrolled in the University of Kentucky longitudinal aging study who used antihypertensive drugs showed diminished progression to dementia, we used a 3-parameter logistic regression model to compare the rate of progression to dementia for subjects who used any of the five common categories of antihypertensive drugs to those with similar demographic characteristics but who did not use antihypertensives. Regression modeling showed that subjects who used calcium channel blockers (CCBs) but not the other classes of antihypertensives showed a significant decrease in the rate of progression to dementia. Significantly, use of CCBs ameliorated the negative effects of the presence of APOE-4 alleles on cognitive decline. To determine if CCBs could minimize amyloid beta peptide (Aβ (1–42)) production, H4 neuroglioma cultures transfected to overexpress APP were treated with various CCBs and Aβ (1–42) levels and levels of proteins involved in Aβ production were quantified. Results show that treatment with nifedipine led to a significant decrease in levels of Aβ (1–42), with no significant decrease in cell viability. Collectively, these data suggest that use of CCBs significantly diminishes the rate of progression to dementia and may minimize formation of Aβ (1–42). Hindawi Publishing Corporation 2015 2015-06-28 /pmc/articles/PMC4499419/ /pubmed/26221415 http://dx.doi.org/10.1155/2015/787805 Text en Copyright © 2015 Mark A. Lovell et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lovell, Mark A. Abner, Erin Kryscio, Richard Xu, Liou Fister, Shuling X. Lynn, Bert C. Calcium Channel Blockers, Progression to Dementia, and Effects on Amyloid Beta Peptide Production |
title | Calcium Channel Blockers, Progression to Dementia, and Effects on Amyloid Beta Peptide Production |
title_full | Calcium Channel Blockers, Progression to Dementia, and Effects on Amyloid Beta Peptide Production |
title_fullStr | Calcium Channel Blockers, Progression to Dementia, and Effects on Amyloid Beta Peptide Production |
title_full_unstemmed | Calcium Channel Blockers, Progression to Dementia, and Effects on Amyloid Beta Peptide Production |
title_short | Calcium Channel Blockers, Progression to Dementia, and Effects on Amyloid Beta Peptide Production |
title_sort | calcium channel blockers, progression to dementia, and effects on amyloid beta peptide production |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499419/ https://www.ncbi.nlm.nih.gov/pubmed/26221415 http://dx.doi.org/10.1155/2015/787805 |
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