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Second salvage treatment for local recurrence of prostate cancer using high-dose-rate brachytherapy: a case report

PURPOSE: Currently, there are no recommendations for the management of a second local recurrence of prostate adenocarcinoma except for the introduction of androgen deprivation therapy (ADT). CASE REPORT: A 69-year-old man underwent a third salvage local treatment with high-dose-rate brachytherapy (H...

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Autores principales: Claren, Audrey, Gautier, Mathieu, Feuillade, Julien, Falk, Alexander Tuan, Levi, Jean-Michel Hannoun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499512/
https://www.ncbi.nlm.nih.gov/pubmed/26207114
http://dx.doi.org/10.5114/jcb.2015.51852
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author Claren, Audrey
Gautier, Mathieu
Feuillade, Julien
Falk, Alexander Tuan
Levi, Jean-Michel Hannoun
author_facet Claren, Audrey
Gautier, Mathieu
Feuillade, Julien
Falk, Alexander Tuan
Levi, Jean-Michel Hannoun
author_sort Claren, Audrey
collection PubMed
description PURPOSE: Currently, there are no recommendations for the management of a second local recurrence of prostate adenocarcinoma except for the introduction of androgen deprivation therapy (ADT). CASE REPORT: A 69-year-old man underwent a third salvage local treatment with high-dose-rate brachytherapy (HDRB), for a second biochemical relapse for local recurrence. Thirty-five Grays in 5 fractions were delivered on the whole prostate extended to the proximal part of left seminal vesicle. Given the availability of new treatment techniques in our radiation therapy department, a dosimetric comparison between HDRB and stereoatactic radiosurgery (SRS) was performed. RESULTS: Immediate tolerance of HDRB was acceptable with achievement of prostate specific antigen (PSA) nadir in 24 months (0.03 ng/ml). Observed late toxicities were only grade 2 urinary incontinence. Dosimetric comparison showed a slight advantage on clinical target volume coverage and rectum protection for the SRS. The HDRB showed an advantage on bone irradiation including femoral heads and the volume receiving 0.5 Gy (EQD2 = 1 Gy with α/β = 3). CONCLUSIONS: A third local treatment with good tolerance could be a therapeutic option in case of a second local prostate cancer recurrence in order to delay, as long as possible, the chemical castration. Both techniques (HDRB and SRS) seem valid and should be chosen based on the availability and experience in a treatment center.
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spelling pubmed-44995122015-07-23 Second salvage treatment for local recurrence of prostate cancer using high-dose-rate brachytherapy: a case report Claren, Audrey Gautier, Mathieu Feuillade, Julien Falk, Alexander Tuan Levi, Jean-Michel Hannoun J Contemp Brachytherapy Case Report PURPOSE: Currently, there are no recommendations for the management of a second local recurrence of prostate adenocarcinoma except for the introduction of androgen deprivation therapy (ADT). CASE REPORT: A 69-year-old man underwent a third salvage local treatment with high-dose-rate brachytherapy (HDRB), for a second biochemical relapse for local recurrence. Thirty-five Grays in 5 fractions were delivered on the whole prostate extended to the proximal part of left seminal vesicle. Given the availability of new treatment techniques in our radiation therapy department, a dosimetric comparison between HDRB and stereoatactic radiosurgery (SRS) was performed. RESULTS: Immediate tolerance of HDRB was acceptable with achievement of prostate specific antigen (PSA) nadir in 24 months (0.03 ng/ml). Observed late toxicities were only grade 2 urinary incontinence. Dosimetric comparison showed a slight advantage on clinical target volume coverage and rectum protection for the SRS. The HDRB showed an advantage on bone irradiation including femoral heads and the volume receiving 0.5 Gy (EQD2 = 1 Gy with α/β = 3). CONCLUSIONS: A third local treatment with good tolerance could be a therapeutic option in case of a second local prostate cancer recurrence in order to delay, as long as possible, the chemical castration. Both techniques (HDRB and SRS) seem valid and should be chosen based on the availability and experience in a treatment center. Termedia Publishing House 2015-05-28 2015-06 /pmc/articles/PMC4499512/ /pubmed/26207114 http://dx.doi.org/10.5114/jcb.2015.51852 Text en Copyright © 2015 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Claren, Audrey
Gautier, Mathieu
Feuillade, Julien
Falk, Alexander Tuan
Levi, Jean-Michel Hannoun
Second salvage treatment for local recurrence of prostate cancer using high-dose-rate brachytherapy: a case report
title Second salvage treatment for local recurrence of prostate cancer using high-dose-rate brachytherapy: a case report
title_full Second salvage treatment for local recurrence of prostate cancer using high-dose-rate brachytherapy: a case report
title_fullStr Second salvage treatment for local recurrence of prostate cancer using high-dose-rate brachytherapy: a case report
title_full_unstemmed Second salvage treatment for local recurrence of prostate cancer using high-dose-rate brachytherapy: a case report
title_short Second salvage treatment for local recurrence of prostate cancer using high-dose-rate brachytherapy: a case report
title_sort second salvage treatment for local recurrence of prostate cancer using high-dose-rate brachytherapy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499512/
https://www.ncbi.nlm.nih.gov/pubmed/26207114
http://dx.doi.org/10.5114/jcb.2015.51852
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