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APOBEC3 Deletion is Associated with Breast Cancer Risk in a Sample of Southeast Iranian Population

Breast Cancer (BC) is considered as one of the most important causes of death worldwide. Previous studies showed that apolipoprotein B mRNA- editing catalytic polypeptide-like 3 (APOBEC3) gene deletion significantly increased the risk of BC risk in Chinese and European women. The present study aimed...

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Autores principales: Rezaei, Maryam, Hashemi, Mohammad, Hashemi, Seyed Mehdi, Mashhadi, Mohammad Ali, Taheri, Mohsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499572/
https://www.ncbi.nlm.nih.gov/pubmed/26261799
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author Rezaei, Maryam
Hashemi, Mohammad
Hashemi, Seyed Mehdi
Mashhadi, Mohammad Ali
Taheri, Mohsen
author_facet Rezaei, Maryam
Hashemi, Mohammad
Hashemi, Seyed Mehdi
Mashhadi, Mohammad Ali
Taheri, Mohsen
author_sort Rezaei, Maryam
collection PubMed
description Breast Cancer (BC) is considered as one of the most important causes of death worldwide. Previous studies showed that apolipoprotein B mRNA- editing catalytic polypeptide-like 3 (APOBEC3) gene deletion significantly increased the risk of BC risk in Chinese and European women. The present study aimed to assess the possible impact of APOBEC3 deletion and the risk of BC in a sample of Iranian population. The APOBEC3 insertion/deletion (I/D) was analyzed in a case- control study including 262 BC patients and 217 healthy women. Polymerase chain reaction (PCR) was used to genotype the variant in APOBEC3 gene. The findings of this study showed that I/D as well as I/D+D/D genotype increased the risk of BC (OR= 1.57, 95% CI= 1.07- 2.31, p= 0.025 and OR= 1.50, 95% CI= 1.03- 2.19, p= 0.037, respectively) in comparison with I/I genotype. In conclusion, our findings suggest that APOBEC3 deletion polymorphism increased the risk of BC in an Iranian population in the southeast of Iran.
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spelling pubmed-44995722015-08-10 APOBEC3 Deletion is Associated with Breast Cancer Risk in a Sample of Southeast Iranian Population Rezaei, Maryam Hashemi, Mohammad Hashemi, Seyed Mehdi Mashhadi, Mohammad Ali Taheri, Mohsen Int J Mol Cell Med Original Article Breast Cancer (BC) is considered as one of the most important causes of death worldwide. Previous studies showed that apolipoprotein B mRNA- editing catalytic polypeptide-like 3 (APOBEC3) gene deletion significantly increased the risk of BC risk in Chinese and European women. The present study aimed to assess the possible impact of APOBEC3 deletion and the risk of BC in a sample of Iranian population. The APOBEC3 insertion/deletion (I/D) was analyzed in a case- control study including 262 BC patients and 217 healthy women. Polymerase chain reaction (PCR) was used to genotype the variant in APOBEC3 gene. The findings of this study showed that I/D as well as I/D+D/D genotype increased the risk of BC (OR= 1.57, 95% CI= 1.07- 2.31, p= 0.025 and OR= 1.50, 95% CI= 1.03- 2.19, p= 0.037, respectively) in comparison with I/I genotype. In conclusion, our findings suggest that APOBEC3 deletion polymorphism increased the risk of BC in an Iranian population in the southeast of Iran. Babol University of Medical Sciences 2015 /pmc/articles/PMC4499572/ /pubmed/26261799 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Rezaei, Maryam
Hashemi, Mohammad
Hashemi, Seyed Mehdi
Mashhadi, Mohammad Ali
Taheri, Mohsen
APOBEC3 Deletion is Associated with Breast Cancer Risk in a Sample of Southeast Iranian Population
title APOBEC3 Deletion is Associated with Breast Cancer Risk in a Sample of Southeast Iranian Population
title_full APOBEC3 Deletion is Associated with Breast Cancer Risk in a Sample of Southeast Iranian Population
title_fullStr APOBEC3 Deletion is Associated with Breast Cancer Risk in a Sample of Southeast Iranian Population
title_full_unstemmed APOBEC3 Deletion is Associated with Breast Cancer Risk in a Sample of Southeast Iranian Population
title_short APOBEC3 Deletion is Associated with Breast Cancer Risk in a Sample of Southeast Iranian Population
title_sort apobec3 deletion is associated with breast cancer risk in a sample of southeast iranian population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499572/
https://www.ncbi.nlm.nih.gov/pubmed/26261799
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