Programmed Hydrolysis in Designing Paclitaxel Prodrug for Nanocarrier Assembly

Nanocarriers delivering prodrugs are a way of improving in vivo effectiveness and efficiency. For therapeutic efficacy, the prodrug must hydrolyze to its parent drug after administration. Based on the fact that the hydrolysis is impeded by steric hindrance and improved by sufficient polarity, in thi...

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Detalles Bibliográficos
Autores principales: Fu, Q., Wang, Y., Ma, Y., Zhang, D., Fallon, J. K., Yang, X., Liu, D., He, Z., Liu, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499798/
https://www.ncbi.nlm.nih.gov/pubmed/26166066
http://dx.doi.org/10.1038/srep12023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499798/
https://www.ncbi.nlm.nih.gov/pubmed/26166066
http://dx.doi.org/10.1038/srep12023

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