Cargando…
Programmed Hydrolysis in Designing Paclitaxel Prodrug for Nanocarrier Assembly
Nanocarriers delivering prodrugs are a way of improving in vivo effectiveness and efficiency. For therapeutic efficacy, the prodrug must hydrolyze to its parent drug after administration. Based on the fact that the hydrolysis is impeded by steric hindrance and improved by sufficient polarity, in thi...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499798/ https://www.ncbi.nlm.nih.gov/pubmed/26166066 http://dx.doi.org/10.1038/srep12023 |