Skp2-MacroH2A1-CDK8 axis orchestrates G2/M transition, polyploidy and tumourigenesis

Understanding the mechanism by which cell growth, migration, polyploidy, and tumourigenesis are regulated may provide important therapeutic strategies for cancer therapy. Here we identify the Skp2-macroH2A1 (mH2A1)-CDK8 axis as a critical pathway for these processes, and deregulation of this pathway...

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Detalles Bibliográficos
Autores principales: Xu, Dazhi, Li, Chien-Feng, Zhang, Xian, Gong, Zhaohui, Chan, Chia-Hsin, Lee, Szu-Wei, Jin, Guoxiang, Rezaeian, Abdol-Hossein, Han, Fei, Wang, Jing, Yang, Wei-Lei, Feng, Zi-Zhen, Chen, Wei, Wu, Ching-Yuan, Wang, Ying-Jan, Chow, Lu-Ping, Zhu, Xiao-Feng, Zeng, Yi-Xin, Lin, Hui-Kuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500169/
https://www.ncbi.nlm.nih.gov/pubmed/25818643
http://dx.doi.org/10.1038/ncomms7641

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