Dynamic regulation of cardiolipin by the lipid pump, ATP8b1, determines the severity of lung injury in experimental bacterial pneumonia

Pneumonia remains the leading cause of infectious deaths and yet fundamentally new conceptual models underlying its pathogenesis have not emerged. Patients and mice with bacterial pneumonia have marked elevations of cardiolipin in lung fluid, a rare, mitochondrial-specific phospholipid that potently...

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Detalles Bibliográficos
Autores principales: Ray, Nancy B., Durairaj, Lakshmi, Chen, Bill B., McVerry, Bryan J., Ryan, Alan J., Donahoe, Michael, Waltenbaugh, Alisa K., O’Donnell, Christopher P., Henderson, Florita C., Etscheidt, Christopher A., McCoy, Diann M., Agassandian, Marianna, Hayes-Rowan, Emily C., Coon, Tiffany A., Butler, Phillip L., Gakhar, Lokesh, Mathur, Satya N., Sieren, Jessica C., Tyurina, Yulia Y., Kagan, Valerian E., McLennan, Geoffrey, Mallampalli, Rama K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500192/
https://www.ncbi.nlm.nih.gov/pubmed/20852622
http://dx.doi.org/10.1038/nm.2213

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