The role of epoxyeicosatrienoic acids in the cardiovascular system

There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of...

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Detalles Bibliográficos
Autores principales: Yang, L, Mäki-Petäjä, K, Cheriyan, J, McEniery, C, Wilkinson, I B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2015
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500322/
https://www.ncbi.nlm.nih.gov/pubmed/25655310
http://dx.doi.org/10.1111/bcp.12603
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author Yang, L
Mäki-Petäjä, K
Cheriyan, J
McEniery, C
Wilkinson, I B
author_facet Yang, L
Mäki-Petäjä, K
Cheriyan, J
McEniery, C
Wilkinson, I B
author_sort Yang, L
collection PubMed
description There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of cardiovascular risk factors. This review discusses the current knowledge on the role of EETs in endothelium-dependent control of vascular tone in the healthy and in subjects with cardiovascular risk factors, and considers the pharmacological potential of targeting this pathway.
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spelling pubmed-45003222015-08-13 The role of epoxyeicosatrienoic acids in the cardiovascular system Yang, L Mäki-Petäjä, K Cheriyan, J McEniery, C Wilkinson, I B Br J Clin Pharmacol Reviews There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of cardiovascular risk factors. This review discusses the current knowledge on the role of EETs in endothelium-dependent control of vascular tone in the healthy and in subjects with cardiovascular risk factors, and considers the pharmacological potential of targeting this pathway. Blackwell Publishing Ltd 2015-07 2015-02-05 /pmc/articles/PMC4500322/ /pubmed/25655310 http://dx.doi.org/10.1111/bcp.12603 Text en © 2015 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Yang, L
Mäki-Petäjä, K
Cheriyan, J
McEniery, C
Wilkinson, I B
The role of epoxyeicosatrienoic acids in the cardiovascular system
title The role of epoxyeicosatrienoic acids in the cardiovascular system
title_full The role of epoxyeicosatrienoic acids in the cardiovascular system
title_fullStr The role of epoxyeicosatrienoic acids in the cardiovascular system
title_full_unstemmed The role of epoxyeicosatrienoic acids in the cardiovascular system
title_short The role of epoxyeicosatrienoic acids in the cardiovascular system
title_sort role of epoxyeicosatrienoic acids in the cardiovascular system
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500322/
https://www.ncbi.nlm.nih.gov/pubmed/25655310
http://dx.doi.org/10.1111/bcp.12603
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