Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans

BACKGROUND AND PURPOSE: Hypoxic conditions favour the reduction of nitrite to nitric oxide (NO) to elicit vasodilatation, but the mechanism(s) responsible for bioconversion remains ill defined. In the present study, we assess the role of aldehyde dehydrogenase 2 (ALDH2) in nitrite bioactivation unde...

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Detalles Bibliográficos
Autores principales: Arif, Sayqa, Borgognone, Alessandra, Lin, Erica Lai-Sze, O'Sullivan, Aine G, Sharma, Vishal, Drury, Nigel E, Menon, Ashvini, Nightingale, Peter, Mascaro, Jorge, Bonser, Robert S, Horowitz, John D, Feelisch, Martin, Frenneaux, Michael P, Madhani, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500370/
https://www.ncbi.nlm.nih.gov/pubmed/25754766
http://dx.doi.org/10.1111/bph.13122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500370/
https://www.ncbi.nlm.nih.gov/pubmed/25754766
http://dx.doi.org/10.1111/bph.13122

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