Cargando…

Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans

BACKGROUND AND PURPOSE: Hypoxic conditions favour the reduction of nitrite to nitric oxide (NO) to elicit vasodilatation, but the mechanism(s) responsible for bioconversion remains ill defined. In the present study, we assess the role of aldehyde dehydrogenase 2 (ALDH2) in nitrite bioactivation unde...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arif, Sayqa, Borgognone, Alessandra, Lin, Erica Lai-Sze, O'Sullivan, Aine G, Sharma, Vishal, Drury, Nigel E, Menon, Ashvini, Nightingale, Peter, Mascaro, Jorge, Bonser, Robert S, Horowitz, John D, Feelisch, Martin, Frenneaux, Michael P, Madhani, Melanie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500370/ https://www.ncbi.nlm.nih.gov/pubmed/25754766 http://dx.doi.org/10.1111/bph.13122

Ejemplares similares

Effect of nitrite treatment on endothelial nitric oxide synthase in human left ventricle biopsy
por: Bailey, Jenna, et al.
Publicado: (2013)

Short-Term Intravenous Sodium Nitrite Infusion Improves Cardiac and Pulmonary Hemodynamics in Heart Failure Patients
por: Ormerod, Julian O.M., et al.
Publicado: (2015)

Nitrite is a cGMP generator in isolated platelets
por: Borgognone, Alessandra, et al.
Publicado: (2015)

Human Second Window Pre-Conditioning and Post-Conditioning by Nitrite Is Influenced by a Common Polymorphism in Mitochondrial Aldehyde Dehydrogenase
por: Ormerod, Julian O.M., et al.
Publicado: (2017)

The role of vascular myoglobin in nitrite-mediated blood vessel relaxation
por: Ormerod, Julian O.M., et al.
Publicado: (2011)

Nitrite circumvents platelet resistance to nitric oxide in patients with heart failure preserved ejection fraction and chronic atrial fibrillation
por: Borgognone, Alessandra, et al.
Publicado: (2018)

Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling
por: Feelisch, Martin, et al.
Publicado: (2020)

Inorganic nitrate and nitrite supplementation fails to improve skeletal muscle mitochondrial efficiency in mice and humans
por: Ntessalen, Maria, et al.
Publicado: (2020)

Nitrite-Mediated Hypoxic Vasodilation Predicted from Mathematical Modeling and Quantified from in Vivo Studies in Rat Mesentery
por: Buerk, Donald G., et al.
Publicado: (2017)

Nitrite, vasodilation, and headache in bacterial meningitis: Theoretical approach
por: Wiwanitkit, Viroj
Publicado: (2013)

Protocol: does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI)
por: Siddiqi, Nishat, et al.
Publicado: (2013)

Crosstalk between Nitrite, Myoglobin and Reactive Oxygen Species to Regulate Vasodilation under Hypoxia
por: Totzeck, Matthias, et al.
Publicado: (2014)

Dual role of the L-arginine–ADMA–NO pathway in systemic hypoxic vasodilation and pulmonary hypoxic vasoconstriction
por: Böger, Rainer, et al.
Publicado: (2020)

0099. Nitrite reductase activity during sepsis
por: Simon, V, et al.
Publicado: (2014)

Putting xanthine oxidoreductase and aldehyde oxidase on the NO metabolism map: Nitrite reduction by molybdoenzymes()
por: Maia, Luisa B., et al.
Publicado: (2018)

Inorganic Nitrate in Angina Study: A Randomized Double‐Blind Placebo‐Controlled Trial
por: Schwarz, Konstantin, et al.
Publicado: (2017)

Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)
por: Siddiqi, Nishat, et al.
Publicado: (2014)

Non-endothelial endothelin counteracts hypoxic vasodilation in porcine large coronary arteries
por: Hedegaard, Elise R, et al.
Publicado: (2011)

Phosphorylated vasodilator-stimulated phosphoprotein (P-VASP(Ser239)) in platelets is increased by nitrite and partially deoxygenated erythrocytes
por: Srihirun, Sirada, et al.
Publicado: (2018)

Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT‐targeted therapy
por: Otsuki, Yuji, et al.
Publicado: (2019)

Hypoxically Induced Nitric Oxide: Potential Role as a Vasodilator in Mytilus edulis Gills
por: González, Paula Mariela, et al.
Publicado: (2019)

Nebulization of the acidified sodium nitrite formulation attenuates acute hypoxic pulmonary vasoconstriction
por: Egemnazarov, Bakytbek, et al.
Publicado: (2010)

New mechanisms of normoxic and hypoxic cGMP signalling mediated by the nitrite anion
por: Champion, Hunter
Publicado: (2013)

Diversity and relative abundance of ammonia- and nitrite-oxidizing microorganisms in the offshore Namibian hypoxic zone
por: Lau, Evan, et al.
Publicado: (2019)

Cysteine hydropersulfide reduces lipid peroxidation and protects against myocardial ischaemia-reperfusion injury - Are endogenous persulfides mediators of ischaemic preconditioning?
por: Griffiths, Kayleigh, et al.
Publicado: (2023)

Hemoglobin and cerebral hypoxic vasodilation in humans: Evidence for nitric oxide-dependent and S-nitrosothiol mediated signal transduction
por: Hoiland, Ryan L, et al.
Publicado: (2023)

Delayed Post-Hypoxic Leukoencephalopathy Following Nitrite Poisoning: A Case Report and Review of the Literature
por: Chen, Yankun, et al.
Publicado: (2022)

Nitrosopersulfide (SSNO(-)) targets soluble guanylyl cyclase and induces vasodilation in vivo
por: Cortese-Krott, Miriam M, et al.
Publicado: (2015)

The Capacity of Red Blood Cells to Reduce Nitrite Determines Nitric Oxide Generation under Hypoxic Conditions
por: Fens, Marcel H., et al.
Publicado: (2014)

Neuroprotective role of nitric oxide inhalation and nitrite in a Neonatal Rat Model of Hypoxic-Ischemic Injury
por: Jung, Peter, et al.
Publicado: (2022)

Mechanistic Insights into Inorganic Nitrite-Mediated Vasodilation of Isolated Aortic Rings under Oxidative/Hypertensive Conditions and S-Nitros(yl)ation of Proteins in Germ-Free Mice
por: Stamm, Paul, et al.
Publicado: (2022)

Nitrite mediated vasorelaxation in human chorionic plate vessels is enhanced by hypoxia and dependent on the NO-sGC-cGMP pathway
por: Tropea, Teresa, et al.
Publicado: (2018)

Vasodilator substances of the tissues
por: Tansey, E. M.
Publicado: (1987)

A robust and versatile mass spectrometry platform for comprehensive assessment of the thiol redox metabolome
por: Sutton, T.R., et al.
Publicado: (2018)

Hypoxic NO-donor nitrite protects sGC-dependently against morbidity and mortality associated with sterile inflammatory shock in mice
por: Cauwels, A, et al.
Publicado: (2011)

Boletus edulis Nitrite Reductase Reduces Nitrite Content of Pickles and Mitigates Intoxication in Nitrite-intoxicated Mice
por: Zhang, Weiwei, et al.
Publicado: (2015)

Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm
por: Loudon, Brodie L, et al.
Publicado: (2016)

GLP‐1 Is a Coronary Artery Vasodilator in Humans
por: Clarke, Sophie J., et al.
Publicado: (2018)

White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation
por: Kishimoto, Shinji, et al.
Publicado: (2022)

Amyl Nitrite
Publicado: (1894)

Cannot write session to /tmp/vufind_sessions/sess_hhbgga91b03p5s8fncdgps8mh3