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Wedelolactone Regulates Lipid Metabolism and Improves Hepatic Steatosis Partly by AMPK Activation and Up-Regulation of Expression of PPARα/LPL and LDLR

Hyperlipidemia is considered one of the greatest risk factors of cardiovascular diseases. We investigated the anti-hyperlipidemic effect and the underlying mechanism of wedelolactone, a plant-derived coumestan, in HepG2 cells and high-fat diet (HFD)−induced hyperlipidemic hamsters. We showed that in...

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Detalles Bibliográficos
Autores principales:	Zhao, Yun, Peng, Lu, Yang, Li-chao, Xu, Xu-dong, Li, Wei-jie, Luo, Xiu-mei, Jin, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500417/ https://www.ncbi.nlm.nih.gov/pubmed/26168156 http://dx.doi.org/10.1371/journal.pone.0132720

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