Chronic Losartan Treatment Up-Regulates AT(1)R and Increases the Heart Vulnerability to Acute Onset of Ischemia and Reperfusion Injury in Male Rats

Inhibition of angiotensin II type 1 receptor (AT(1)R) is an important therapy in the management of hypertension, particularly in the immediate post-myocardial infarction period. Yet, the role of AT(1)R in the acute onset of myocardial ischemia and reperfusion injury still remains controversial. Thus...

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Detalles Bibliográficos
Autores principales: Song, Minwoo A., Dasgupta, Chiranjib, Zhang, Lubo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500443/
https://www.ncbi.nlm.nih.gov/pubmed/26168042
http://dx.doi.org/10.1371/journal.pone.0132712

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