Leukocyte Derived Chemotaxin 2 (ALECT2) Amyloidosis

We describe the first case from India of ALECT2 amyloidosis. An adult Punjabi male presented with progressive renal dysfunction and non-nephrotic range proteinuria. Serum protein electrophoresis and immunofixation were normal, with mildly elevated serum free light chain ratio. A renal biopsy confirm...

Descripción completa

Detalles Bibliográficos
Autores principales: Kulkarni, Uday, Valson, Anna, Korula, Anila, Mathews, Vikram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500494/
https://www.ncbi.nlm.nih.gov/pubmed/26185608
http://dx.doi.org/10.4084/MJHID.2015.043
_version_ 1782380921327976448
author Kulkarni, Uday
Valson, Anna
Korula, Anila
Mathews, Vikram
author_facet Kulkarni, Uday
Valson, Anna
Korula, Anila
Mathews, Vikram
author_sort Kulkarni, Uday
collection PubMed
description We describe the first case from India of ALECT2 amyloidosis. An adult Punjabi male presented with progressive renal dysfunction and non-nephrotic range proteinuria. Serum protein electrophoresis and immunofixation were normal, with mildly elevated serum free light chain ratio. A renal biopsy confirmed the presence of amyloid. Immunohistochemistry was negative for monoclonal light chains. Proteomic analysis confirmed the presence of ALECT2 amyloid. The present case highlights the need for confirmatory testing for typing of amyloid.
format Online
Article
Text
id pubmed-4500494
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Università Cattolica del Sacro Cuore
record_format MEDLINE/PubMed
spelling pubmed-45004942015-07-16 Leukocyte Derived Chemotaxin 2 (ALECT2) Amyloidosis Kulkarni, Uday Valson, Anna Korula, Anila Mathews, Vikram Mediterr J Hematol Infect Dis Case Report We describe the first case from India of ALECT2 amyloidosis. An adult Punjabi male presented with progressive renal dysfunction and non-nephrotic range proteinuria. Serum protein electrophoresis and immunofixation were normal, with mildly elevated serum free light chain ratio. A renal biopsy confirmed the presence of amyloid. Immunohistochemistry was negative for monoclonal light chains. Proteomic analysis confirmed the presence of ALECT2 amyloid. The present case highlights the need for confirmatory testing for typing of amyloid. Università Cattolica del Sacro Cuore 2015-07-01 /pmc/articles/PMC4500494/ /pubmed/26185608 http://dx.doi.org/10.4084/MJHID.2015.043 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kulkarni, Uday
Valson, Anna
Korula, Anila
Mathews, Vikram
Leukocyte Derived Chemotaxin 2 (ALECT2) Amyloidosis
title Leukocyte Derived Chemotaxin 2 (ALECT2) Amyloidosis
title_full Leukocyte Derived Chemotaxin 2 (ALECT2) Amyloidosis
title_fullStr Leukocyte Derived Chemotaxin 2 (ALECT2) Amyloidosis
title_full_unstemmed Leukocyte Derived Chemotaxin 2 (ALECT2) Amyloidosis
title_short Leukocyte Derived Chemotaxin 2 (ALECT2) Amyloidosis
title_sort leukocyte derived chemotaxin 2 (alect2) amyloidosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500494/
https://www.ncbi.nlm.nih.gov/pubmed/26185608
http://dx.doi.org/10.4084/MJHID.2015.043
work_keys_str_mv AT kulkarniuday leukocytederivedchemotaxin2alect2amyloidosis
AT valsonanna leukocytederivedchemotaxin2alect2amyloidosis
AT korulaanila leukocytederivedchemotaxin2alect2amyloidosis
AT mathewsvikram leukocytederivedchemotaxin2alect2amyloidosis

Ejemplares similares