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New p-Substituted Salicylaldehyde Phenylhydrazone Derivatives: Synthesis, Characterization, and Antioxidant Activities
A series of new p-nitrophenylhydrazone derivatives 3a–f were synthesized, characterized, and investigated for their antioxidant activities. These compounds have been synthesized by refluxing (p-nitrophenyl)hydrazine with 4-sub-stituted salicylaldehydes. The structures of the compounds were establish...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Scientia Pharmaceutica
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500568/ https://www.ncbi.nlm.nih.gov/pubmed/26279974 http://dx.doi.org/10.3797/scipharm.1405-04 |
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author | Yorur-Goreci, Cigdem Altas-Kiymaz, Nilay Peksel, Aysegul Bilgin-Eran, Belkis Sonmez, Mustafa |
author_facet | Yorur-Goreci, Cigdem Altas-Kiymaz, Nilay Peksel, Aysegul Bilgin-Eran, Belkis Sonmez, Mustafa |
author_sort | Yorur-Goreci, Cigdem |
collection | PubMed |
description | A series of new p-nitrophenylhydrazone derivatives 3a–f were synthesized, characterized, and investigated for their antioxidant activities. These compounds have been synthesized by refluxing (p-nitrophenyl)hydrazine with 4-sub-stituted salicylaldehydes. The structures of the compounds were established by IR, (1)H- and (13)C-NMR, and MS data. The antioxidant activities (free radical-scavenging activity, reducing power, metal chelating activity, and total anti-oxidant activity) of the hydrazone compounds were evaluated. All of the compounds exhibited significant activities, while compound 3a, with the shortest chain, showed the highest antioxidant activity in all of the tests. |
format | Online Article Text |
id | pubmed-4500568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Scientia Pharmaceutica |
record_format | MEDLINE/PubMed |
spelling | pubmed-45005682015-08-14 New p-Substituted Salicylaldehyde Phenylhydrazone Derivatives: Synthesis, Characterization, and Antioxidant Activities Yorur-Goreci, Cigdem Altas-Kiymaz, Nilay Peksel, Aysegul Bilgin-Eran, Belkis Sonmez, Mustafa Sci Pharm Research Article A series of new p-nitrophenylhydrazone derivatives 3a–f were synthesized, characterized, and investigated for their antioxidant activities. These compounds have been synthesized by refluxing (p-nitrophenyl)hydrazine with 4-sub-stituted salicylaldehydes. The structures of the compounds were established by IR, (1)H- and (13)C-NMR, and MS data. The antioxidant activities (free radical-scavenging activity, reducing power, metal chelating activity, and total anti-oxidant activity) of the hydrazone compounds were evaluated. All of the compounds exhibited significant activities, while compound 3a, with the shortest chain, showed the highest antioxidant activity in all of the tests. Scientia Pharmaceutica 2014-07-01 2014 /pmc/articles/PMC4500568/ /pubmed/26279974 http://dx.doi.org/10.3797/scipharm.1405-04 Text en © Yorur Goreci et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yorur-Goreci, Cigdem Altas-Kiymaz, Nilay Peksel, Aysegul Bilgin-Eran, Belkis Sonmez, Mustafa New p-Substituted Salicylaldehyde Phenylhydrazone Derivatives: Synthesis, Characterization, and Antioxidant Activities |
title | New p-Substituted Salicylaldehyde Phenylhydrazone Derivatives: Synthesis, Characterization, and Antioxidant Activities |
title_full | New p-Substituted Salicylaldehyde Phenylhydrazone Derivatives: Synthesis, Characterization, and Antioxidant Activities |
title_fullStr | New p-Substituted Salicylaldehyde Phenylhydrazone Derivatives: Synthesis, Characterization, and Antioxidant Activities |
title_full_unstemmed | New p-Substituted Salicylaldehyde Phenylhydrazone Derivatives: Synthesis, Characterization, and Antioxidant Activities |
title_short | New p-Substituted Salicylaldehyde Phenylhydrazone Derivatives: Synthesis, Characterization, and Antioxidant Activities |
title_sort | new p-substituted salicylaldehyde phenylhydrazone derivatives: synthesis, characterization, and antioxidant activities |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500568/ https://www.ncbi.nlm.nih.gov/pubmed/26279974 http://dx.doi.org/10.3797/scipharm.1405-04 |
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