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Continuous-Flow Left Ventricular Assist Device Thrombosis: A Danger Foreseen is a Danger Avoided
Left ventricular assist devices (LVAD) are an increasingly implemented therapeutic intervention for patients with end-stage heart failure. A growing body of evidence, however, has shown an elevated risk of device thrombosis, a major complication jeopardizing the patient’s post-implantation survival....
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500598/ https://www.ncbi.nlm.nih.gov/pubmed/26250695 http://dx.doi.org/10.12659/MSMBR.894840 |
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author | Fatullayev, Javid Samak, Mostafa Sabashnikov, Anton Zeriouh, Mohamed Rahmanian, Parwis B. Choi, Yeong-Hoon Schmack, Bastian Kallenbach, Klaus Ruhparwar, Arjang Eghbalzadeh, Kaveh Dohmen, Pascal M. Karck, Matthias Wippermann, Jens Wahlers, Thorsten Popov, Aron-Frederik Simon, Andre R. Weymann, Alexander |
author_facet | Fatullayev, Javid Samak, Mostafa Sabashnikov, Anton Zeriouh, Mohamed Rahmanian, Parwis B. Choi, Yeong-Hoon Schmack, Bastian Kallenbach, Klaus Ruhparwar, Arjang Eghbalzadeh, Kaveh Dohmen, Pascal M. Karck, Matthias Wippermann, Jens Wahlers, Thorsten Popov, Aron-Frederik Simon, Andre R. Weymann, Alexander |
author_sort | Fatullayev, Javid |
collection | PubMed |
description | Left ventricular assist devices (LVAD) are an increasingly implemented therapeutic intervention for patients with end-stage heart failure. A growing body of evidence, however, has shown an elevated risk of device thrombosis, a major complication jeopardizing the patient’s post-implantation survival. To date, multiple causative factors for LVAD thrombosis have been identified, such as internal shear stress, device material, infection, and inadequate anticoagulation. Understanding the mechanisms leading to LVAD thrombosis will not only enable device optimization, but also allow for better patient handling, hence improving post-implantation outcome. In this review we highlight the most commonly identified factors leading to LVAD thrombosis and discuss their mechanisms. |
format | Online Article Text |
id | pubmed-4500598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-45005982015-07-17 Continuous-Flow Left Ventricular Assist Device Thrombosis: A Danger Foreseen is a Danger Avoided Fatullayev, Javid Samak, Mostafa Sabashnikov, Anton Zeriouh, Mohamed Rahmanian, Parwis B. Choi, Yeong-Hoon Schmack, Bastian Kallenbach, Klaus Ruhparwar, Arjang Eghbalzadeh, Kaveh Dohmen, Pascal M. Karck, Matthias Wippermann, Jens Wahlers, Thorsten Popov, Aron-Frederik Simon, Andre R. Weymann, Alexander Med Sci Monit Basic Res Review Articles Left ventricular assist devices (LVAD) are an increasingly implemented therapeutic intervention for patients with end-stage heart failure. A growing body of evidence, however, has shown an elevated risk of device thrombosis, a major complication jeopardizing the patient’s post-implantation survival. To date, multiple causative factors for LVAD thrombosis have been identified, such as internal shear stress, device material, infection, and inadequate anticoagulation. Understanding the mechanisms leading to LVAD thrombosis will not only enable device optimization, but also allow for better patient handling, hence improving post-implantation outcome. In this review we highlight the most commonly identified factors leading to LVAD thrombosis and discuss their mechanisms. International Scientific Literature, Inc. 2015-07-01 /pmc/articles/PMC4500598/ /pubmed/26250695 http://dx.doi.org/10.12659/MSMBR.894840 Text en © Med Sci Monit, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
spellingShingle | Review Articles Fatullayev, Javid Samak, Mostafa Sabashnikov, Anton Zeriouh, Mohamed Rahmanian, Parwis B. Choi, Yeong-Hoon Schmack, Bastian Kallenbach, Klaus Ruhparwar, Arjang Eghbalzadeh, Kaveh Dohmen, Pascal M. Karck, Matthias Wippermann, Jens Wahlers, Thorsten Popov, Aron-Frederik Simon, Andre R. Weymann, Alexander Continuous-Flow Left Ventricular Assist Device Thrombosis: A Danger Foreseen is a Danger Avoided |
title | Continuous-Flow Left Ventricular Assist Device Thrombosis: A Danger Foreseen is a Danger Avoided |
title_full | Continuous-Flow Left Ventricular Assist Device Thrombosis: A Danger Foreseen is a Danger Avoided |
title_fullStr | Continuous-Flow Left Ventricular Assist Device Thrombosis: A Danger Foreseen is a Danger Avoided |
title_full_unstemmed | Continuous-Flow Left Ventricular Assist Device Thrombosis: A Danger Foreseen is a Danger Avoided |
title_short | Continuous-Flow Left Ventricular Assist Device Thrombosis: A Danger Foreseen is a Danger Avoided |
title_sort | continuous-flow left ventricular assist device thrombosis: a danger foreseen is a danger avoided |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500598/ https://www.ncbi.nlm.nih.gov/pubmed/26250695 http://dx.doi.org/10.12659/MSMBR.894840 |
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