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Synthesis of dehydrodipeptide esters and their evaluation as inhibitors of cathepsin C
The procedures for the synthesis of esters of dehydropeptides containing C-terminal (Z)-dehydrophenylalanine and dehydroalanine have been elaborated. These esters appeared to be moderate or weak inhibitors of cathepsin C, with some of them exhibiting slow-binding behavior. As shown by molecular mode...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500854/ https://www.ncbi.nlm.nih.gov/pubmed/26190908 http://dx.doi.org/10.1007/s00044-015-1366-0 |