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Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey

The generation of new neurons in the adult mammalian brain is well-established for the hippocampal dentate gyrus (DG). However, the role of neurogenesis in hippocampal function and cognition, how it changes in aging, and the mechanisms underlying this are yet to be elucidated in the monkey brain. To...

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Autores principales: Ngwenya, Laura B., Heyworth, Nadine C., Shwe, Yamin, Moore, Tara L., Rosene, Douglas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500920/
https://www.ncbi.nlm.nih.gov/pubmed/26236203
http://dx.doi.org/10.3389/fnsys.2015.00102
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author Ngwenya, Laura B.
Heyworth, Nadine C.
Shwe, Yamin
Moore, Tara L.
Rosene, Douglas L.
author_facet Ngwenya, Laura B.
Heyworth, Nadine C.
Shwe, Yamin
Moore, Tara L.
Rosene, Douglas L.
author_sort Ngwenya, Laura B.
collection PubMed
description The generation of new neurons in the adult mammalian brain is well-established for the hippocampal dentate gyrus (DG). However, the role of neurogenesis in hippocampal function and cognition, how it changes in aging, and the mechanisms underlying this are yet to be elucidated in the monkey brain. To address this, we investigated adult neurogenesis in the DG of 42 rhesus monkeys (39 cognitively tested) ranging in age from young adult to the elderly. We report here that there is an age-related decline in proliferation and a delayed development of adult neuronal phenotype. Additionally, we show that many of the new neurons survive throughout the lifetime of the animal and may contribute to a modest increase in total neuron number in the granule cell layer of the DG over the adult life span. Lastly, we find that measures of decreased adult neurogenesis are only modestly predictive of age-related cognitive impairment.
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spelling pubmed-45009202015-07-31 Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey Ngwenya, Laura B. Heyworth, Nadine C. Shwe, Yamin Moore, Tara L. Rosene, Douglas L. Front Syst Neurosci Neuroscience The generation of new neurons in the adult mammalian brain is well-established for the hippocampal dentate gyrus (DG). However, the role of neurogenesis in hippocampal function and cognition, how it changes in aging, and the mechanisms underlying this are yet to be elucidated in the monkey brain. To address this, we investigated adult neurogenesis in the DG of 42 rhesus monkeys (39 cognitively tested) ranging in age from young adult to the elderly. We report here that there is an age-related decline in proliferation and a delayed development of adult neuronal phenotype. Additionally, we show that many of the new neurons survive throughout the lifetime of the animal and may contribute to a modest increase in total neuron number in the granule cell layer of the DG over the adult life span. Lastly, we find that measures of decreased adult neurogenesis are only modestly predictive of age-related cognitive impairment. Frontiers Media S.A. 2015-07-14 /pmc/articles/PMC4500920/ /pubmed/26236203 http://dx.doi.org/10.3389/fnsys.2015.00102 Text en Copyright © 2015 Ngwenya, Heyworth, Shwe, Moore and Rosene. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ngwenya, Laura B.
Heyworth, Nadine C.
Shwe, Yamin
Moore, Tara L.
Rosene, Douglas L.
Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey
title Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey
title_full Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey
title_fullStr Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey
title_full_unstemmed Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey
title_short Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey
title_sort age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500920/
https://www.ncbi.nlm.nih.gov/pubmed/26236203
http://dx.doi.org/10.3389/fnsys.2015.00102
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