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Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs

In recent years, IL-17A (IL-17), a pro-inflammatory cytokine, has received intense attention of researchers and clinicians alike with documented effects in inflammation and autoimmune diseases. IL-17 mobilizes, recruits and activates different cells to increase inflammation. Although protective in i...

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Autores principales: Khan, Deena, Ansar Ahmed, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500956/
https://www.ncbi.nlm.nih.gov/pubmed/26236331
http://dx.doi.org/10.3389/fgene.2015.00236
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author Khan, Deena
Ansar Ahmed, S.
author_facet Khan, Deena
Ansar Ahmed, S.
author_sort Khan, Deena
collection PubMed
description In recent years, IL-17A (IL-17), a pro-inflammatory cytokine, has received intense attention of researchers and clinicians alike with documented effects in inflammation and autoimmune diseases. IL-17 mobilizes, recruits and activates different cells to increase inflammation. Although protective in infections, overproduction of IL-17 promotes inflammation in autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, psoriasis, among others. Regulating IL-17 levels or action by using IL-17-blocking antibodies or IL-17R antagonist has shown to attenuate experimental autoimmune diseases. It is now known that in addition to IL-17-specific transcription factor, RORγt, several other transcription factors and select microRNAs (miRNA) regulate IL-17. Given that miRNAs are dysregulated in autoimmune diseases, a better understanding of transcriptional factors and miRNA regulation of IL-17 expression and function will be essential for devising potential new therapies. In this review, we will overview IL-17 induction and function in relation to autoimmune diseases. In addition, current findings on transcriptional regulation of IL-17 induction and plausible interplay between IL-17 and miRNA in autoimmune diseases are highlighted.
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spelling pubmed-45009562015-07-31 Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs Khan, Deena Ansar Ahmed, S. Front Genet Genetics In recent years, IL-17A (IL-17), a pro-inflammatory cytokine, has received intense attention of researchers and clinicians alike with documented effects in inflammation and autoimmune diseases. IL-17 mobilizes, recruits and activates different cells to increase inflammation. Although protective in infections, overproduction of IL-17 promotes inflammation in autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, psoriasis, among others. Regulating IL-17 levels or action by using IL-17-blocking antibodies or IL-17R antagonist has shown to attenuate experimental autoimmune diseases. It is now known that in addition to IL-17-specific transcription factor, RORγt, several other transcription factors and select microRNAs (miRNA) regulate IL-17. Given that miRNAs are dysregulated in autoimmune diseases, a better understanding of transcriptional factors and miRNA regulation of IL-17 expression and function will be essential for devising potential new therapies. In this review, we will overview IL-17 induction and function in relation to autoimmune diseases. In addition, current findings on transcriptional regulation of IL-17 induction and plausible interplay between IL-17 and miRNA in autoimmune diseases are highlighted. Frontiers Media S.A. 2015-07-14 /pmc/articles/PMC4500956/ /pubmed/26236331 http://dx.doi.org/10.3389/fgene.2015.00236 Text en Copyright © 2015 Khan and Ansar Ahmed. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Khan, Deena
Ansar Ahmed, S.
Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs
title Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs
title_full Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs
title_fullStr Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs
title_full_unstemmed Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs
title_short Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs
title_sort regulation of il-17 in autoimmune diseases by transcriptional factors and micrornas
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500956/
https://www.ncbi.nlm.nih.gov/pubmed/26236331
http://dx.doi.org/10.3389/fgene.2015.00236
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