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Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B
AIM: To compare the performance of several simple, noninvasive models comprising various serum markers in diagnosing significant liver fibrosis in the same sample of patients with chronic hepatitis B (CHB) with the same judgment standard. METHODS: A total of 308 patients with CHB who had undergone l...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Croatian Medical Schools
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500965/ https://www.ncbi.nlm.nih.gov/pubmed/26088852 http://dx.doi.org/10.3325/cmj.2015.56.272 |
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author | Zeng, Xianghua Xu, Cheng He, Dengming Li, Maoshi Zhang, Huiyan Wu, Quanxin Xiang, Dedong Wang, Yuming |
author_facet | Zeng, Xianghua Xu, Cheng He, Dengming Li, Maoshi Zhang, Huiyan Wu, Quanxin Xiang, Dedong Wang, Yuming |
author_sort | Zeng, Xianghua |
collection | PubMed |
description | AIM: To compare the performance of several simple, noninvasive models comprising various serum markers in diagnosing significant liver fibrosis in the same sample of patients with chronic hepatitis B (CHB) with the same judgment standard. METHODS: A total of 308 patients with CHB who had undergone liver biopsy, laboratory tests, and liver stiffness measurement (LSM) at the Southwest Hospital, Chongqing, China between March 2010 and April 2014 were retrospectively studied. Receiver operating characteristic (ROC) curves and area under ROC curves (AUROCs) were used to analyze the results of the models, which incorporated age-platelet (PLT) index (API model), aspartate transaminase (AST) to alanine aminotransferase (ALT) ratio (AAR model), AST to PLT ratio index (APRI model), γ-glutamyl transpeptidase (GGT) to PLT ratio index (GPRI model), GGT-PLT-albumin index (S index model), age-AST-PLT-ALT index (FIB-4 model), and age-AST-PLT-ALT-international normalized ratio index (Fibro-Q model). RESULTS: The AUROCs of the S index, GPRI, FIB-4, APRI, API, Fibro-Q, AAR, and LSM for predicting significant liver fibrosis were 0.726 (P < 0.001), 0.726 (P < 0.001), 0.621 (P = 0.001), 0.619 (P = 0.001), 0.580 (P = 0.033), 0.569 (P = 0.066), 0.495 (P = 0.886), and 0.757 (P < 0.001), respectively. The S index and GPRI had the highest correlation with histopathological scores (r = 0.373, P < 0.001; r = 0.372, P < 0.001, respectively) and LSM values (r = 0.516, P < 0.001; r = 0.513, P < 0.001, respectively). When LSM was combined with S index and GPRI, the AUROCs were 0.753 (P < 0.001) and 0.746 (P < 0.001), respectively. CONCLUSION: S index and GPRI had the best diagnostic performance for significant liver fibrosis and were robust predictors of significant liver fibrosis in patients with CHB for whom transient elastography was unavailable. |
format | Online Article Text |
id | pubmed-4500965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Croatian Medical Schools |
record_format | MEDLINE/PubMed |
spelling | pubmed-45009652015-07-16 Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B Zeng, Xianghua Xu, Cheng He, Dengming Li, Maoshi Zhang, Huiyan Wu, Quanxin Xiang, Dedong Wang, Yuming Croat Med J Clinical Science AIM: To compare the performance of several simple, noninvasive models comprising various serum markers in diagnosing significant liver fibrosis in the same sample of patients with chronic hepatitis B (CHB) with the same judgment standard. METHODS: A total of 308 patients with CHB who had undergone liver biopsy, laboratory tests, and liver stiffness measurement (LSM) at the Southwest Hospital, Chongqing, China between March 2010 and April 2014 were retrospectively studied. Receiver operating characteristic (ROC) curves and area under ROC curves (AUROCs) were used to analyze the results of the models, which incorporated age-platelet (PLT) index (API model), aspartate transaminase (AST) to alanine aminotransferase (ALT) ratio (AAR model), AST to PLT ratio index (APRI model), γ-glutamyl transpeptidase (GGT) to PLT ratio index (GPRI model), GGT-PLT-albumin index (S index model), age-AST-PLT-ALT index (FIB-4 model), and age-AST-PLT-ALT-international normalized ratio index (Fibro-Q model). RESULTS: The AUROCs of the S index, GPRI, FIB-4, APRI, API, Fibro-Q, AAR, and LSM for predicting significant liver fibrosis were 0.726 (P < 0.001), 0.726 (P < 0.001), 0.621 (P = 0.001), 0.619 (P = 0.001), 0.580 (P = 0.033), 0.569 (P = 0.066), 0.495 (P = 0.886), and 0.757 (P < 0.001), respectively. The S index and GPRI had the highest correlation with histopathological scores (r = 0.373, P < 0.001; r = 0.372, P < 0.001, respectively) and LSM values (r = 0.516, P < 0.001; r = 0.513, P < 0.001, respectively). When LSM was combined with S index and GPRI, the AUROCs were 0.753 (P < 0.001) and 0.746 (P < 0.001), respectively. CONCLUSION: S index and GPRI had the best diagnostic performance for significant liver fibrosis and were robust predictors of significant liver fibrosis in patients with CHB for whom transient elastography was unavailable. Croatian Medical Schools 2015-06 /pmc/articles/PMC4500965/ /pubmed/26088852 http://dx.doi.org/10.3325/cmj.2015.56.272 Text en Copyright © 2015 by the Croatian Medical Journal. All rights reserved. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Science Zeng, Xianghua Xu, Cheng He, Dengming Li, Maoshi Zhang, Huiyan Wu, Quanxin Xiang, Dedong Wang, Yuming Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B |
title | Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B |
title_full | Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B |
title_fullStr | Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B |
title_full_unstemmed | Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B |
title_short | Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B |
title_sort | performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis b |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500965/ https://www.ncbi.nlm.nih.gov/pubmed/26088852 http://dx.doi.org/10.3325/cmj.2015.56.272 |
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