Cargando…

Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B

AIM: To compare the performance of several simple, noninvasive models comprising various serum markers in diagnosing significant liver fibrosis in the same sample of patients with chronic hepatitis B (CHB) with the same judgment standard. METHODS: A total of 308 patients with CHB who had undergone l...

Descripción completa

Detalles Bibliográficos
Autores principales: Zeng, Xianghua, Xu, Cheng, He, Dengming, Li, Maoshi, Zhang, Huiyan, Wu, Quanxin, Xiang, Dedong, Wang, Yuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Medical Schools 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500965/
https://www.ncbi.nlm.nih.gov/pubmed/26088852
http://dx.doi.org/10.3325/cmj.2015.56.272
_version_ 1782380986774847488
author Zeng, Xianghua
Xu, Cheng
He, Dengming
Li, Maoshi
Zhang, Huiyan
Wu, Quanxin
Xiang, Dedong
Wang, Yuming
author_facet Zeng, Xianghua
Xu, Cheng
He, Dengming
Li, Maoshi
Zhang, Huiyan
Wu, Quanxin
Xiang, Dedong
Wang, Yuming
author_sort Zeng, Xianghua
collection PubMed
description AIM: To compare the performance of several simple, noninvasive models comprising various serum markers in diagnosing significant liver fibrosis in the same sample of patients with chronic hepatitis B (CHB) with the same judgment standard. METHODS: A total of 308 patients with CHB who had undergone liver biopsy, laboratory tests, and liver stiffness measurement (LSM) at the Southwest Hospital, Chongqing, China between March 2010 and April 2014 were retrospectively studied. Receiver operating characteristic (ROC) curves and area under ROC curves (AUROCs) were used to analyze the results of the models, which incorporated age-platelet (PLT) index (API model), aspartate transaminase (AST) to alanine aminotransferase (ALT) ratio (AAR model), AST to PLT ratio index (APRI model), γ-glutamyl transpeptidase (GGT) to PLT ratio index (GPRI model), GGT-PLT-albumin index (S index model), age-AST-PLT-ALT index (FIB-4 model), and age-AST-PLT-ALT-international normalized ratio index (Fibro-Q model). RESULTS: The AUROCs of the S index, GPRI, FIB-4, APRI, API, Fibro-Q, AAR, and LSM for predicting significant liver fibrosis were 0.726 (P < 0.001), 0.726 (P < 0.001), 0.621 (P = 0.001), 0.619 (P = 0.001), 0.580 (P = 0.033), 0.569 (P = 0.066), 0.495 (P = 0.886), and 0.757 (P < 0.001), respectively. The S index and GPRI had the highest correlation with histopathological scores (r = 0.373, P < 0.001; r = 0.372, P < 0.001, respectively) and LSM values (r = 0.516, P < 0.001; r = 0.513, P < 0.001, respectively). When LSM was combined with S index and GPRI, the AUROCs were 0.753 (P < 0.001) and 0.746 (P < 0.001), respectively. CONCLUSION: S index and GPRI had the best diagnostic performance for significant liver fibrosis and were robust predictors of significant liver fibrosis in patients with CHB for whom transient elastography was unavailable.
format Online
Article
Text
id pubmed-4500965
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Croatian Medical Schools
record_format MEDLINE/PubMed
spelling pubmed-45009652015-07-16 Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B Zeng, Xianghua Xu, Cheng He, Dengming Li, Maoshi Zhang, Huiyan Wu, Quanxin Xiang, Dedong Wang, Yuming Croat Med J Clinical Science AIM: To compare the performance of several simple, noninvasive models comprising various serum markers in diagnosing significant liver fibrosis in the same sample of patients with chronic hepatitis B (CHB) with the same judgment standard. METHODS: A total of 308 patients with CHB who had undergone liver biopsy, laboratory tests, and liver stiffness measurement (LSM) at the Southwest Hospital, Chongqing, China between March 2010 and April 2014 were retrospectively studied. Receiver operating characteristic (ROC) curves and area under ROC curves (AUROCs) were used to analyze the results of the models, which incorporated age-platelet (PLT) index (API model), aspartate transaminase (AST) to alanine aminotransferase (ALT) ratio (AAR model), AST to PLT ratio index (APRI model), γ-glutamyl transpeptidase (GGT) to PLT ratio index (GPRI model), GGT-PLT-albumin index (S index model), age-AST-PLT-ALT index (FIB-4 model), and age-AST-PLT-ALT-international normalized ratio index (Fibro-Q model). RESULTS: The AUROCs of the S index, GPRI, FIB-4, APRI, API, Fibro-Q, AAR, and LSM for predicting significant liver fibrosis were 0.726 (P < 0.001), 0.726 (P < 0.001), 0.621 (P = 0.001), 0.619 (P = 0.001), 0.580 (P = 0.033), 0.569 (P = 0.066), 0.495 (P = 0.886), and 0.757 (P < 0.001), respectively. The S index and GPRI had the highest correlation with histopathological scores (r = 0.373, P < 0.001; r = 0.372, P < 0.001, respectively) and LSM values (r = 0.516, P < 0.001; r = 0.513, P < 0.001, respectively). When LSM was combined with S index and GPRI, the AUROCs were 0.753 (P < 0.001) and 0.746 (P < 0.001), respectively. CONCLUSION: S index and GPRI had the best diagnostic performance for significant liver fibrosis and were robust predictors of significant liver fibrosis in patients with CHB for whom transient elastography was unavailable. Croatian Medical Schools 2015-06 /pmc/articles/PMC4500965/ /pubmed/26088852 http://dx.doi.org/10.3325/cmj.2015.56.272 Text en Copyright © 2015 by the Croatian Medical Journal. All rights reserved. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Science
Zeng, Xianghua
Xu, Cheng
He, Dengming
Li, Maoshi
Zhang, Huiyan
Wu, Quanxin
Xiang, Dedong
Wang, Yuming
Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B
title Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B
title_full Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B
title_fullStr Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B
title_full_unstemmed Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B
title_short Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B
title_sort performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis b
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500965/
https://www.ncbi.nlm.nih.gov/pubmed/26088852
http://dx.doi.org/10.3325/cmj.2015.56.272
work_keys_str_mv AT zengxianghua performanceofseveralsimplenoninvasivemodelsforassessingsignificantliverfibrosisinpatientswithchronichepatitisb
AT xucheng performanceofseveralsimplenoninvasivemodelsforassessingsignificantliverfibrosisinpatientswithchronichepatitisb
AT hedengming performanceofseveralsimplenoninvasivemodelsforassessingsignificantliverfibrosisinpatientswithchronichepatitisb
AT limaoshi performanceofseveralsimplenoninvasivemodelsforassessingsignificantliverfibrosisinpatientswithchronichepatitisb
AT zhanghuiyan performanceofseveralsimplenoninvasivemodelsforassessingsignificantliverfibrosisinpatientswithchronichepatitisb
AT wuquanxin performanceofseveralsimplenoninvasivemodelsforassessingsignificantliverfibrosisinpatientswithchronichepatitisb
AT xiangdedong performanceofseveralsimplenoninvasivemodelsforassessingsignificantliverfibrosisinpatientswithchronichepatitisb
AT wangyuming performanceofseveralsimplenoninvasivemodelsforassessingsignificantliverfibrosisinpatientswithchronichepatitisb