Preliminary Characterization and In Vivo Studies of Structurally Identical (18)F- and (125)I-Labeled Benzyloxybenzenes for PET/SPECT Imaging of β-Amyloid Plaques

With the assistance of molecular docking and 3D-QSAR models established previously, structurally identical (18)F- and (125)I-labeled benzyloxybenzene derivatives were designed to achieve the early detection of Aβ plaques by PET/SPECT imaging. In competition binding assay, ligands 7a and 12a displaye...

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Detalles Bibliográficos
Autores principales: Yang, Yanping, Zhang, Xiaoyang, Cui, Mengchao, Zhang, Jinming, Guo, Zhide, Li, Yesen, Zhang, Xianzhong, Dai, Jiapei, Liu, Boli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501006/
https://www.ncbi.nlm.nih.gov/pubmed/26170205
http://dx.doi.org/10.1038/srep12084

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