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NKCC1 downregulation induces hyperpolarizing shift of GABA responsiveness at near term fetal stages in rat cultured dorsal root ganglion neurons
BACKGROUND: GABA(A) receptor-mediated neurotransmission is greatly influenced by cation-chloride cotransporter activity during developmental stages. In embryonic neurons Na–K–2Cl (NKCC1) cotransporters mediate active chloride uptake, thus increasing the intracellular chloride concentration associate...
Autores principales: | Chabwine, Joelle N, Talavera, Karel, Van Den Bosch, Ludo, Callewaert, Geert |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501047/ https://www.ncbi.nlm.nih.gov/pubmed/26169500 http://dx.doi.org/10.1186/s12868-015-0180-4 |
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