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In vivo analysis of Nef’s role in HIV-1 replication, systemic T cell activation and CD4(+) T cell loss
BACKGROUND: Nef is a multifunctional HIV-1 protein critical for progression to AIDS. Humans infected with nef(−) HIV-1 have greatly delayed or no disease consequences. We have contrasted nef(−) and nef(+) infection of BLT humanized mice to better characterize Nef’s pathogenic effects. RESULTS: Mice...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501112/ https://www.ncbi.nlm.nih.gov/pubmed/26169178 http://dx.doi.org/10.1186/s12977-015-0187-z |