In vivo analysis of Nef’s role in HIV-1 replication, systemic T cell activation and CD4(+) T cell loss

BACKGROUND: Nef is a multifunctional HIV-1 protein critical for progression to AIDS. Humans infected with nef(−) HIV-1 have greatly delayed or no disease consequences. We have contrasted nef(−) and nef(+) infection of BLT humanized mice to better characterize Nef’s pathogenic effects. RESULTS: Mice...

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Detalles Bibliográficos
Autores principales: Watkins, Richard L, Foster, John L, Garcia, J Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501112/
https://www.ncbi.nlm.nih.gov/pubmed/26169178
http://dx.doi.org/10.1186/s12977-015-0187-z

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