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Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers

BACKGROUND: Topical application of the synthetic triterpenoid RTA 408 to rodents elicits a potent dermal cytoprotective phenotype through activation of the transcription factor Nrf2. Therefore, studies were conducted to investigate if such cytoprotective properties translate to human dermal cells, a...

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Detalles Bibliográficos
Autores principales:	Reisman, Scott A., Goldsberry, Angela R., Lee, Chun-Yue I., O’Grady, Megan L., Proksch, Joel W., Ward, Keith W., Meyer, Colin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501113/ https://www.ncbi.nlm.nih.gov/pubmed/26170027 http://dx.doi.org/10.1186/s12895-015-0029-7

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