A double-blind, randomized, placebo-controlled trial studying the effects of Saccharomyces boulardii on the gastrointestinal tolerability, safety, and pharmacokinetics of miglustat

BACKGROUND: Gastrointestinal (GI) disturbances such as diarrhea and flatulence are the most frequent adverse effects associated with miglustat therapy in type 1 Gaucher disease (GD1) and Niemann-Pick disease type C (NP-C), and the most common recorded reason for stopping treatment during clinical tr...

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Detalles Bibliográficos
Autores principales: Remenova, Tatiana, Morand, Olivier, Amato, Dominick, Chadha-Boreham, Harbajan, Tsurutani, Scott, Marquardt, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501118/
https://www.ncbi.nlm.nih.gov/pubmed/26084276
http://dx.doi.org/10.1186/s13023-015-0297-7

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