Inhibition of hexokinase-2 with targeted liposomal 3-bromopyruvate in an ovarian tumor spheroid model of aerobic glycolysis

BACKGROUND: The objective of this study was to evaluate the expression levels of glycolytic markers, especially hexokinase-2 (HK2), using a three-dimensional multicellular spheroid model of human ovarian adenocarcinoma (SKOV-3) cells and to develop an epidermal growth factor receptor-targeted liposo...

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Detalles Bibliográficos
Autores principales: Gandham, Srujan Kumar, Talekar, Meghna, Singh, Amit, Amiji, Mansoor M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501223/
https://www.ncbi.nlm.nih.gov/pubmed/26185443
http://dx.doi.org/10.2147/IJN.S82818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501223/
https://www.ncbi.nlm.nih.gov/pubmed/26185443
http://dx.doi.org/10.2147/IJN.S82818

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