Altered protease and antiprotease balance during a COPD exacerbation contributes to mucus obstruction

BACKGROUND: Proteases have been shown to degrade airway mucin proteins and to damage the epithelium impairing mucociliary clearance. There are increased proteases in the COPD airway but changes in protease-antiprotease balance and mucin degradation have not been investigated during the course of a C...

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Detalles Bibliográficos
Autores principales: Chillappagari, Shashi, Preuss, Jenni, Licht, Sebastian, Müller, Christian, Mahavadi, Poornima, Sarode, Gaurav, Vogelmeier, Claus, Guenther, Andreas, Nahrlich, Lutz, Rubin, Bruce K., Henke, Markus O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501272/
https://www.ncbi.nlm.nih.gov/pubmed/26169056
http://dx.doi.org/10.1186/s12931-015-0247-x

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