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Discovery of Selective Small-Molecule Activators of a Bacterial Glycoside Hydrolase**

Fragment-based approaches are used routinely to discover enzyme inhibitors as cellular tools and potential therapeutic agents. There have been few reports, however, of the discovery of small-molecule enzyme activators. Herein, we describe the discovery and characterization of small-molecule activato...

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Detalles Bibliográficos
Autores principales:	Darby, John F, Landström, Jens, Roth, Christian, He, Yuan, Davies, Gideon J, Hubbard, Roderick E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2014
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501319/ https://www.ncbi.nlm.nih.gov/pubmed/25291993 http://dx.doi.org/10.1002/anie.201407081

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