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Cellular context–mediated Akt dynamics regulates MAP kinase signaling thresholds during angiogenesis
The formation of new blood vessels by sprouting angiogenesis is tightly regulated by contextual cues that affect angiogeneic growth factor signaling. Both constitutive activation and loss of Akt kinase activity in endothelial cells impair angiogenesis, suggesting that Akt dynamics mediates contextua...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501366/ https://www.ncbi.nlm.nih.gov/pubmed/26023089 http://dx.doi.org/10.1091/mbc.E14-09-1378 |