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The Minimal k-Core Problem for Modeling k-Assemblies

The concept of cell assembly was introduced by Hebb and formalized mathematically by Palm in the framework of graph theory. In the study of associative memory, a cell assembly is a group of neurons that are strongly connected and represent a “concept” of our knowledge. This group is wired in a speci...

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Detalles Bibliográficos
Autores principales: Wood, Cynthia I., Hicks, Illya V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501374/
https://www.ncbi.nlm.nih.gov/pubmed/26169718
http://dx.doi.org/10.1186/s13408-015-0027-4
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author Wood, Cynthia I.
Hicks, Illya V.
author_facet Wood, Cynthia I.
Hicks, Illya V.
author_sort Wood, Cynthia I.
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description The concept of cell assembly was introduced by Hebb and formalized mathematically by Palm in the framework of graph theory. In the study of associative memory, a cell assembly is a group of neurons that are strongly connected and represent a “concept” of our knowledge. This group is wired in a specific manner such that only a fraction of its neurons will excite the entire assembly. We link the concept of cell assembly to the closure of a minimal k-core and study a particular type of cell assembly called k-assembly. The goal of this paper is to find all substructures within a network that must be excited in order to activate a k-assembly. Through numerical experiments, we confirm that fractions of these important subgroups overlap. To explore the problem, we present a backtracking algorithm to find all minimal k-cores of a given undirected graph, which belongs to the class of NP-hard problems. The proposed method is a modification of the Bron and Kerbosch algorithm for finding all cliques of an undirected graph. The results in the tested graphs offer insight in analyzing graph structure and help better understand how concepts are stored.
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spelling pubmed-45013742015-07-17 The Minimal k-Core Problem for Modeling k-Assemblies Wood, Cynthia I. Hicks, Illya V. J Math Neurosci Research The concept of cell assembly was introduced by Hebb and formalized mathematically by Palm in the framework of graph theory. In the study of associative memory, a cell assembly is a group of neurons that are strongly connected and represent a “concept” of our knowledge. This group is wired in a specific manner such that only a fraction of its neurons will excite the entire assembly. We link the concept of cell assembly to the closure of a minimal k-core and study a particular type of cell assembly called k-assembly. The goal of this paper is to find all substructures within a network that must be excited in order to activate a k-assembly. Through numerical experiments, we confirm that fractions of these important subgroups overlap. To explore the problem, we present a backtracking algorithm to find all minimal k-cores of a given undirected graph, which belongs to the class of NP-hard problems. The proposed method is a modification of the Bron and Kerbosch algorithm for finding all cliques of an undirected graph. The results in the tested graphs offer insight in analyzing graph structure and help better understand how concepts are stored. Springer Berlin Heidelberg 2015-07-14 /pmc/articles/PMC4501374/ /pubmed/26169718 http://dx.doi.org/10.1186/s13408-015-0027-4 Text en © Wood and Hicks 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Wood, Cynthia I.
Hicks, Illya V.
The Minimal k-Core Problem for Modeling k-Assemblies
title The Minimal k-Core Problem for Modeling k-Assemblies
title_full The Minimal k-Core Problem for Modeling k-Assemblies
title_fullStr The Minimal k-Core Problem for Modeling k-Assemblies
title_full_unstemmed The Minimal k-Core Problem for Modeling k-Assemblies
title_short The Minimal k-Core Problem for Modeling k-Assemblies
title_sort minimal k-core problem for modeling k-assemblies
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501374/
https://www.ncbi.nlm.nih.gov/pubmed/26169718
http://dx.doi.org/10.1186/s13408-015-0027-4
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