In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures

We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half maximal inhibitory concentrationvalues in the range of 6-18 µM. In the cytoto...

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Detalles Bibliográficos
Autores principales: Lavorato, Stefânia Neiva, Sales, Policarpo Ademar, Murta, Silvane Maria Fonseca, Romanha, Alvaro José, Alves/, Ricardo José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501422/
https://www.ncbi.nlm.nih.gov/pubmed/26061148
http://dx.doi.org/10.1590/0074-02760150007
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author Lavorato, Stefânia Neiva
Sales, Policarpo Ademar
Murta, Silvane Maria Fonseca
Romanha, Alvaro José
Alves/, Ricardo José
author_facet Lavorato, Stefânia Neiva
Sales, Policarpo Ademar
Murta, Silvane Maria Fonseca
Romanha, Alvaro José
Alves/, Ricardo José
author_sort Lavorato, Stefânia Neiva
collection PubMed
description We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half maximal inhibitory concentrationvalues in the range of 6-18 µM. In the cytotoxicity tests against L929 cells, only compound 4 presented selectivity index value above 10, indicating low toxicity.
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spelling pubmed-45014222015-07-16 In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures Lavorato, Stefânia Neiva Sales, Policarpo Ademar Murta, Silvane Maria Fonseca Romanha, Alvaro José Alves/, Ricardo José Mem Inst Oswaldo Cruz Short Communication We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half maximal inhibitory concentrationvalues in the range of 6-18 µM. In the cytotoxicity tests against L929 cells, only compound 4 presented selectivity index value above 10, indicating low toxicity. Instituto Oswaldo Cruz, Ministério da Saúde 2015-06 /pmc/articles/PMC4501422/ /pubmed/26061148 http://dx.doi.org/10.1590/0074-02760150007 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Lavorato, Stefânia Neiva
Sales, Policarpo Ademar
Murta, Silvane Maria Fonseca
Romanha, Alvaro José
Alves/, Ricardo José
In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
title In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
title_full In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
title_fullStr In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
title_full_unstemmed In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
title_short In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
title_sort in vitro activity of 1,3-bisaryloxypropanamines against trypanosoma cruzi-infected l929 cultures
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501422/
https://www.ncbi.nlm.nih.gov/pubmed/26061148
http://dx.doi.org/10.1590/0074-02760150007
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