Draft genome sequences of three NDM-1-producing Enterobacteriaceae species isolated from Brazil

The emergence of multidrug-resistant Enterobacteriaceae strains producing carbapenemases, such as NDM-1, has become a major public health issue due to a high dissemination capacity and limited treatment options. Here we describe the draft genome of three NDM-1-producing isolates: Providencia rettger...

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Detalles Bibliográficos
Autores principales: Pereira, Polyana Silva, Albano, Rodolpho Mattos, Asensi, Marise Dutra, Carvalho-Assef, Ana Paula D’Alincourt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2015
Materias:
Genome Announcement and Highlights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501426/
https://www.ncbi.nlm.nih.gov/pubmed/26061151
http://dx.doi.org/10.1590/0074-02760150081
Descripción
Sumario:The emergence of multidrug-resistant Enterobacteriaceae strains producing carbapenemases, such as NDM-1, has become a major public health issue due to a high dissemination capacity and limited treatment options. Here we describe the draft genome of three NDM-1-producing isolates: Providencia rettgeri (CCBH11880), Enterobacter hormaechei subsp. oharae (CCBH10892) and Klebsiella pneumoniae (CCBH13327), isolated in Brazil. Besides bla(NDM-1), resistance genes to aminoglycosides [aadA1, aadA2, aac(6’)-Ib-cr] and quinolones (qnrA1, qnrB4) were observed which contributed to the multidrug resistance profile. The element ISAba125 was found associated to the bla(NDM-1) gene in all strains.

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