Cargando…

Successful treatment with carboplatin and nanoparticle albumin-bound paclitaxel in a patient with pulmonary spindle cell carcinoma

INTRODUCTION: Pulmonary spindle cell carcinoma (SpCC) is a rare subtype of non-small-cell lung cancer (NSCLC) and, in general, is chemoresistance. CASE: A sixty-five year-old male patient with metastatic pulmonary SpCC was initially treated with cisplatin and docetaxel, but his disease progressed. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsuji, Takahiro, Kim, Young Hak, Ozasa, Hiroaki, Sakamori, Yuichi, Nagai, Hiroki, Ajimizu, Hitomi, Yagi, Yoshitaka, Furukawa, Atsuyuki, Haga, Hironori, Mishima, Michiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501525/
https://www.ncbi.nlm.nih.gov/pubmed/26236601
http://dx.doi.org/10.1016/j.rmcr.2015.05.003
_version_ 1782381080304680960
author Tsuji, Takahiro
Kim, Young Hak
Ozasa, Hiroaki
Sakamori, Yuichi
Nagai, Hiroki
Ajimizu, Hitomi
Yagi, Yoshitaka
Furukawa, Atsuyuki
Haga, Hironori
Mishima, Michiaki
author_facet Tsuji, Takahiro
Kim, Young Hak
Ozasa, Hiroaki
Sakamori, Yuichi
Nagai, Hiroki
Ajimizu, Hitomi
Yagi, Yoshitaka
Furukawa, Atsuyuki
Haga, Hironori
Mishima, Michiaki
author_sort Tsuji, Takahiro
collection PubMed
description INTRODUCTION: Pulmonary spindle cell carcinoma (SpCC) is a rare subtype of non-small-cell lung cancer (NSCLC) and, in general, is chemoresistance. CASE: A sixty-five year-old male patient with metastatic pulmonary SpCC was initially treated with cisplatin and docetaxel, but his disease progressed. Then, he received a combination chemotherapy with carboplatin and nab-PTX followed by maintenanced chemotherapy with nab-PTX. Fluorodeoxyglucose (FDG) positron-emission CT revealed a substantial decrease of FDG accumulation in the primary tumor, and the response continued for more than 7 months. DISCUSSION: Preclinical models suggested that nab-PTX may reach the tumor microenvironment more efficiently than solvent-based paclitaxel (sb-PTX) and be preferentially taken up by cancer cells. Considering that there is no effective treatment for patients with pulmonary SpCC, nab-PTX may merit further investigation in patients with pulmonary SpCC.
format Online
Article
Text
id pubmed-4501525
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-45015252015-08-01 Successful treatment with carboplatin and nanoparticle albumin-bound paclitaxel in a patient with pulmonary spindle cell carcinoma Tsuji, Takahiro Kim, Young Hak Ozasa, Hiroaki Sakamori, Yuichi Nagai, Hiroki Ajimizu, Hitomi Yagi, Yoshitaka Furukawa, Atsuyuki Haga, Hironori Mishima, Michiaki Respir Med Case Rep Case Report INTRODUCTION: Pulmonary spindle cell carcinoma (SpCC) is a rare subtype of non-small-cell lung cancer (NSCLC) and, in general, is chemoresistance. CASE: A sixty-five year-old male patient with metastatic pulmonary SpCC was initially treated with cisplatin and docetaxel, but his disease progressed. Then, he received a combination chemotherapy with carboplatin and nab-PTX followed by maintenanced chemotherapy with nab-PTX. Fluorodeoxyglucose (FDG) positron-emission CT revealed a substantial decrease of FDG accumulation in the primary tumor, and the response continued for more than 7 months. DISCUSSION: Preclinical models suggested that nab-PTX may reach the tumor microenvironment more efficiently than solvent-based paclitaxel (sb-PTX) and be preferentially taken up by cancer cells. Considering that there is no effective treatment for patients with pulmonary SpCC, nab-PTX may merit further investigation in patients with pulmonary SpCC. Elsevier 2015-05-15 /pmc/articles/PMC4501525/ /pubmed/26236601 http://dx.doi.org/10.1016/j.rmcr.2015.05.003 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tsuji, Takahiro
Kim, Young Hak
Ozasa, Hiroaki
Sakamori, Yuichi
Nagai, Hiroki
Ajimizu, Hitomi
Yagi, Yoshitaka
Furukawa, Atsuyuki
Haga, Hironori
Mishima, Michiaki
Successful treatment with carboplatin and nanoparticle albumin-bound paclitaxel in a patient with pulmonary spindle cell carcinoma
title Successful treatment with carboplatin and nanoparticle albumin-bound paclitaxel in a patient with pulmonary spindle cell carcinoma
title_full Successful treatment with carboplatin and nanoparticle albumin-bound paclitaxel in a patient with pulmonary spindle cell carcinoma
title_fullStr Successful treatment with carboplatin and nanoparticle albumin-bound paclitaxel in a patient with pulmonary spindle cell carcinoma
title_full_unstemmed Successful treatment with carboplatin and nanoparticle albumin-bound paclitaxel in a patient with pulmonary spindle cell carcinoma
title_short Successful treatment with carboplatin and nanoparticle albumin-bound paclitaxel in a patient with pulmonary spindle cell carcinoma
title_sort successful treatment with carboplatin and nanoparticle albumin-bound paclitaxel in a patient with pulmonary spindle cell carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501525/
https://www.ncbi.nlm.nih.gov/pubmed/26236601
http://dx.doi.org/10.1016/j.rmcr.2015.05.003
work_keys_str_mv AT tsujitakahiro successfultreatmentwithcarboplatinandnanoparticlealbuminboundpaclitaxelinapatientwithpulmonaryspindlecellcarcinoma
AT kimyounghak successfultreatmentwithcarboplatinandnanoparticlealbuminboundpaclitaxelinapatientwithpulmonaryspindlecellcarcinoma
AT ozasahiroaki successfultreatmentwithcarboplatinandnanoparticlealbuminboundpaclitaxelinapatientwithpulmonaryspindlecellcarcinoma
AT sakamoriyuichi successfultreatmentwithcarboplatinandnanoparticlealbuminboundpaclitaxelinapatientwithpulmonaryspindlecellcarcinoma
AT nagaihiroki successfultreatmentwithcarboplatinandnanoparticlealbuminboundpaclitaxelinapatientwithpulmonaryspindlecellcarcinoma
AT ajimizuhitomi successfultreatmentwithcarboplatinandnanoparticlealbuminboundpaclitaxelinapatientwithpulmonaryspindlecellcarcinoma
AT yagiyoshitaka successfultreatmentwithcarboplatinandnanoparticlealbuminboundpaclitaxelinapatientwithpulmonaryspindlecellcarcinoma
AT furukawaatsuyuki successfultreatmentwithcarboplatinandnanoparticlealbuminboundpaclitaxelinapatientwithpulmonaryspindlecellcarcinoma
AT hagahironori successfultreatmentwithcarboplatinandnanoparticlealbuminboundpaclitaxelinapatientwithpulmonaryspindlecellcarcinoma
AT mishimamichiaki successfultreatmentwithcarboplatinandnanoparticlealbuminboundpaclitaxelinapatientwithpulmonaryspindlecellcarcinoma