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Minocycline-induced acute eosinophilic pneumonia: A case report and review of the literature()
Acute eosinophilic pneumonia (AEP) can be a challenging diagnosis and is often initially misdiagnosed as one of the more common pneumonia syndromes such as acute respiratory distress syndrome. Early bronchoalveolar lavage (BAL) is critical in distinguishing the diagnosis to initiate proper managemen...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elsevier
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501541/ https://www.ncbi.nlm.nih.gov/pubmed/26236618 http://dx.doi.org/10.1016/j.rmcr.2015.05.013 |
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author | Hung, Sharon W. |
author_facet | Hung, Sharon W. |
author_sort | Hung, Sharon W. |
collection | PubMed |
description | Acute eosinophilic pneumonia (AEP) can be a challenging diagnosis and is often initially misdiagnosed as one of the more common pneumonia syndromes such as acute respiratory distress syndrome. Early bronchoalveolar lavage (BAL) is critical in distinguishing the diagnosis to initiate proper management. The etiology of AEP is unknown, though many drugs have been implicated, including minocycline. Minocycline is commonly used for pneumonia, acute bronchitis, urinary tract infections, and acne and is likely the cause of AEP in our patient. There are 26 case reports of minocycline-induced AEP. In most cases, outcomes were favorable and symptoms rapidly resolved upon discontinuation of minocycline, with 11 cases employing steroids, one case twelve hours of CPAP and another 5 days of intubation. None resulted in mortality. Although it is difficult to evaluate without further studies, steroids should be recommended for minocycline-induced AEP, especially for those with severe or persistent symptoms. |
format | Online Article Text |
id | pubmed-4501541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-45015412015-08-01 Minocycline-induced acute eosinophilic pneumonia: A case report and review of the literature() Hung, Sharon W. Respir Med Case Rep Case Report Acute eosinophilic pneumonia (AEP) can be a challenging diagnosis and is often initially misdiagnosed as one of the more common pneumonia syndromes such as acute respiratory distress syndrome. Early bronchoalveolar lavage (BAL) is critical in distinguishing the diagnosis to initiate proper management. The etiology of AEP is unknown, though many drugs have been implicated, including minocycline. Minocycline is commonly used for pneumonia, acute bronchitis, urinary tract infections, and acne and is likely the cause of AEP in our patient. There are 26 case reports of minocycline-induced AEP. In most cases, outcomes were favorable and symptoms rapidly resolved upon discontinuation of minocycline, with 11 cases employing steroids, one case twelve hours of CPAP and another 5 days of intubation. None resulted in mortality. Although it is difficult to evaluate without further studies, steroids should be recommended for minocycline-induced AEP, especially for those with severe or persistent symptoms. Elsevier 2015-05-30 /pmc/articles/PMC4501541/ /pubmed/26236618 http://dx.doi.org/10.1016/j.rmcr.2015.05.013 Text en © 2015 The Author http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Hung, Sharon W. Minocycline-induced acute eosinophilic pneumonia: A case report and review of the literature() |
title | Minocycline-induced acute eosinophilic pneumonia: A case report and review of the literature() |
title_full | Minocycline-induced acute eosinophilic pneumonia: A case report and review of the literature() |
title_fullStr | Minocycline-induced acute eosinophilic pneumonia: A case report and review of the literature() |
title_full_unstemmed | Minocycline-induced acute eosinophilic pneumonia: A case report and review of the literature() |
title_short | Minocycline-induced acute eosinophilic pneumonia: A case report and review of the literature() |
title_sort | minocycline-induced acute eosinophilic pneumonia: a case report and review of the literature() |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501541/ https://www.ncbi.nlm.nih.gov/pubmed/26236618 http://dx.doi.org/10.1016/j.rmcr.2015.05.013 |
work_keys_str_mv | AT hungsharonw minocyclineinducedacuteeosinophilicpneumoniaacasereportandreviewoftheliterature |