Virtual and In Vitro Screens Reveal a Potential Pharmacophore that Avoids the Fibrillization of Aβ(1–42)

Among the multiple factors that induce Alzheimer’s disease, aggregation of the amyloid β peptide (Aβ) is considered the most important due to the ability of the 42-amino acid Aβ peptides (Aβ(1–42)) to form oligomers and fibrils, which constitute Aβ pathological aggregates. For this reason, the devel...

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Detalles Bibliográficos
Autores principales: Hernández-Rodríguez, Maricarmen, Correa-Basurto, José, Nicolás-Vázquez, María Inés, Miranda-Ruvalcaba, René, Benítez-Cardoza, Claudia Guadalupe, Reséndiz-Albor, Aldo Arturo, Méndez-Méndez, Juan Vicente, Rosales-Hernández, Martha C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501547/
https://www.ncbi.nlm.nih.gov/pubmed/26172152
http://dx.doi.org/10.1371/journal.pone.0130263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501547/
https://www.ncbi.nlm.nih.gov/pubmed/26172152
http://dx.doi.org/10.1371/journal.pone.0130263

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