Caveolin-1 Dependent Endocytosis Enhances the Chemosensitivity of HER-2 Positive Breast Cancer Cells to Trastuzumab Emtansine (T-DM1)

The humanized monoclonal antibody-drug conjugate trastuzumab emtansine (T-DM1, Kadcyla) has been approved by the U.S. FDA to treat human epidermal growth factor receptor 2 (HER-2)-positive metastatic breast cancer. Despite its effectiveness in most patients, some are initially resistant or develop r...

Descripción completa

Detalles Bibliográficos
Autores principales: Chung, Yuan-Chiang, Kuo, Jang-Fang, Wei, Wan-Chen, Chang, King-Jen, Chao, Wei-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501549/
https://www.ncbi.nlm.nih.gov/pubmed/26172389
http://dx.doi.org/10.1371/journal.pone.0133072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501549/
https://www.ncbi.nlm.nih.gov/pubmed/26172389
http://dx.doi.org/10.1371/journal.pone.0133072

Ejemplares similares