Allelic Variants in Arhgef11 via the Rho-Rock Pathway Are Linked to Epithelial–Mesenchymal Transition and Contributes to Kidney Injury in the Dahl Salt-Sensitive Rat

Previously, genetic analyses identified that variants in Arhgef11 may influence kidney injury in the Dahl salt-sensitive (S) rat, a model of hypertensive chronic kidney disease. To understand the potential mechanism by which altered expression and/or protein differences in Arhgef11 could play a role...

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Detalles Bibliográficos
Autores principales: Jia, Zhen, Johnson, Ashley C., Wang, Xuexiang, Guo, Zibiao, Dreisbach, Albert W., Lewin, Jack R., Kyle, Patrick B., Garrett, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501567/
https://www.ncbi.nlm.nih.gov/pubmed/26172442
http://dx.doi.org/10.1371/journal.pone.0132553

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