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Localization and upregulation of survivin in cancer health disparities: a clinical perspective
Survivin is one of the most important members of the inhibitors of apoptosis protein family, as it is expressed in most human cancers but is absent in normal, differentiated tissues. Lending to its importance, survivin has proven associations with apoptosis and cell cycle control, and has more recen...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501680/ https://www.ncbi.nlm.nih.gov/pubmed/26185415 http://dx.doi.org/10.2147/BTT.S83864 |
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author | Khan, Salma Ferguson Bennit, Heather Asuncion Valenzuela, Malyn May Turay, David Diaz Osterman, Carlos J Moyron, Ron B Esebanmen, Grace E Ashok, Arjun Wall, Nathan R |
author_facet | Khan, Salma Ferguson Bennit, Heather Asuncion Valenzuela, Malyn May Turay, David Diaz Osterman, Carlos J Moyron, Ron B Esebanmen, Grace E Ashok, Arjun Wall, Nathan R |
author_sort | Khan, Salma |
collection | PubMed |
description | Survivin is one of the most important members of the inhibitors of apoptosis protein family, as it is expressed in most human cancers but is absent in normal, differentiated tissues. Lending to its importance, survivin has proven associations with apoptosis and cell cycle control, and has more recently been shown to modulate the tumor microenvironment and immune evasion as a result of its extracellular localization. Upregulation of survivin has been found in many cancers including breast, prostate, pancreatic, and hematological malignancies, and it may prove to be associated with the advanced presentation, poorer prognosis, and lower survival rates observed in ethnically diverse populations. |
format | Online Article Text |
id | pubmed-4501680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-45016802015-07-16 Localization and upregulation of survivin in cancer health disparities: a clinical perspective Khan, Salma Ferguson Bennit, Heather Asuncion Valenzuela, Malyn May Turay, David Diaz Osterman, Carlos J Moyron, Ron B Esebanmen, Grace E Ashok, Arjun Wall, Nathan R Biologics Review Survivin is one of the most important members of the inhibitors of apoptosis protein family, as it is expressed in most human cancers but is absent in normal, differentiated tissues. Lending to its importance, survivin has proven associations with apoptosis and cell cycle control, and has more recently been shown to modulate the tumor microenvironment and immune evasion as a result of its extracellular localization. Upregulation of survivin has been found in many cancers including breast, prostate, pancreatic, and hematological malignancies, and it may prove to be associated with the advanced presentation, poorer prognosis, and lower survival rates observed in ethnically diverse populations. Dove Medical Press 2015-07-09 /pmc/articles/PMC4501680/ /pubmed/26185415 http://dx.doi.org/10.2147/BTT.S83864 Text en © 2015 Khan et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Khan, Salma Ferguson Bennit, Heather Asuncion Valenzuela, Malyn May Turay, David Diaz Osterman, Carlos J Moyron, Ron B Esebanmen, Grace E Ashok, Arjun Wall, Nathan R Localization and upregulation of survivin in cancer health disparities: a clinical perspective |
title | Localization and upregulation of survivin in cancer health disparities: a clinical perspective |
title_full | Localization and upregulation of survivin in cancer health disparities: a clinical perspective |
title_fullStr | Localization and upregulation of survivin in cancer health disparities: a clinical perspective |
title_full_unstemmed | Localization and upregulation of survivin in cancer health disparities: a clinical perspective |
title_short | Localization and upregulation of survivin in cancer health disparities: a clinical perspective |
title_sort | localization and upregulation of survivin in cancer health disparities: a clinical perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501680/ https://www.ncbi.nlm.nih.gov/pubmed/26185415 http://dx.doi.org/10.2147/BTT.S83864 |
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