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A Population-Based Study on the Association between Benign Prostatic Enlargement and Rheumatoid Arthritis

Benign prostatic hyperplasia is one of the chronic inflammatory conditions in ageing male populations. Rheumatoid arthritis (RA) is a major autoimmune disease and is also regarded as a chronic inflammatory disorder. Although RA and benign prostatic enlargement (BPE) may share the same underlying eti...

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Autores principales: Tzeng, Ya-Mei, Kao, Li-Ting, Lin, Herng-Ching, Huang, Chao-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501730/
https://www.ncbi.nlm.nih.gov/pubmed/26172054
http://dx.doi.org/10.1371/journal.pone.0133013
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author Tzeng, Ya-Mei
Kao, Li-Ting
Lin, Herng-Ching
Huang, Chao-Yuan
author_facet Tzeng, Ya-Mei
Kao, Li-Ting
Lin, Herng-Ching
Huang, Chao-Yuan
author_sort Tzeng, Ya-Mei
collection PubMed
description Benign prostatic hyperplasia is one of the chronic inflammatory conditions in ageing male populations. Rheumatoid arthritis (RA) is a major autoimmune disease and is also regarded as a chronic inflammatory disorder. Although RA and benign prostatic enlargement (BPE) may share the same underlying etiologies, almost no study has ever attempted to explore the relationship between RA and BPE. The aim of this study was to explore the relationship between RA and BPE using a population-based dataset. This case-control study used data retrieved from the Taiwan Longitudinal Health Insurance Database 2005. This study comprised 18,716 patients with BPE and 18,716 age-matched patients without BPE. Conditional logistic regression analyses were performed to calculate the odds ratio (OR) for having been previously diagnosed with RA between patients with BPE and comparison patients. In total, 485 of the 37,432 sampled patients (1.3%) had received a prior RA diagnosis. There was a significant difference in the prevalence of prior RA between cases and controls (1.6% vs. 1.0%, p<0.001). After adjusting for patient’s urbanization level, monthly income, geographic region, and obesity, the adjusted OR was 1.54 (95% CI = 1.28~1.85) for patients with BPE compared to comparison patients. In addition, the sensitivity analysis showed that BPE was consistently and significantly associated with a prior RA diagnosis even after excluding subjects diagnosed with RA within 1, 2, or 3 years prior to the index date (the adjusted ORs were 1.46, 1.50, and 1.42, respectively). We concluded that there was a significant association between prior RA and BPE. Further large-scale longitudinal studies are suggested to clarify the causal relationship between RA and BPE.
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spelling pubmed-45017302015-07-17 A Population-Based Study on the Association between Benign Prostatic Enlargement and Rheumatoid Arthritis Tzeng, Ya-Mei Kao, Li-Ting Lin, Herng-Ching Huang, Chao-Yuan PLoS One Research Article Benign prostatic hyperplasia is one of the chronic inflammatory conditions in ageing male populations. Rheumatoid arthritis (RA) is a major autoimmune disease and is also regarded as a chronic inflammatory disorder. Although RA and benign prostatic enlargement (BPE) may share the same underlying etiologies, almost no study has ever attempted to explore the relationship between RA and BPE. The aim of this study was to explore the relationship between RA and BPE using a population-based dataset. This case-control study used data retrieved from the Taiwan Longitudinal Health Insurance Database 2005. This study comprised 18,716 patients with BPE and 18,716 age-matched patients without BPE. Conditional logistic regression analyses were performed to calculate the odds ratio (OR) for having been previously diagnosed with RA between patients with BPE and comparison patients. In total, 485 of the 37,432 sampled patients (1.3%) had received a prior RA diagnosis. There was a significant difference in the prevalence of prior RA between cases and controls (1.6% vs. 1.0%, p<0.001). After adjusting for patient’s urbanization level, monthly income, geographic region, and obesity, the adjusted OR was 1.54 (95% CI = 1.28~1.85) for patients with BPE compared to comparison patients. In addition, the sensitivity analysis showed that BPE was consistently and significantly associated with a prior RA diagnosis even after excluding subjects diagnosed with RA within 1, 2, or 3 years prior to the index date (the adjusted ORs were 1.46, 1.50, and 1.42, respectively). We concluded that there was a significant association between prior RA and BPE. Further large-scale longitudinal studies are suggested to clarify the causal relationship between RA and BPE. Public Library of Science 2015-07-14 /pmc/articles/PMC4501730/ /pubmed/26172054 http://dx.doi.org/10.1371/journal.pone.0133013 Text en © 2015 Tzeng et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Tzeng, Ya-Mei
Kao, Li-Ting
Lin, Herng-Ching
Huang, Chao-Yuan
A Population-Based Study on the Association between Benign Prostatic Enlargement and Rheumatoid Arthritis
title A Population-Based Study on the Association between Benign Prostatic Enlargement and Rheumatoid Arthritis
title_full A Population-Based Study on the Association between Benign Prostatic Enlargement and Rheumatoid Arthritis
title_fullStr A Population-Based Study on the Association between Benign Prostatic Enlargement and Rheumatoid Arthritis
title_full_unstemmed A Population-Based Study on the Association between Benign Prostatic Enlargement and Rheumatoid Arthritis
title_short A Population-Based Study on the Association between Benign Prostatic Enlargement and Rheumatoid Arthritis
title_sort population-based study on the association between benign prostatic enlargement and rheumatoid arthritis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501730/
https://www.ncbi.nlm.nih.gov/pubmed/26172054
http://dx.doi.org/10.1371/journal.pone.0133013
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