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A Developmental Switch for Hebbian Plasticity

Hebbian forms of synaptic plasticity are required for the orderly development of sensory circuits in the brain and are powerful modulators of learning and memory in adulthood. During development, emergence of Hebbian plasticity leads to formation of functional circuits. By modeling the dynamics of n...

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Autores principales: Martens, Marijn B., Celikel, Tansu, Tiesinga, Paul H. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501799/
https://www.ncbi.nlm.nih.gov/pubmed/26172394
http://dx.doi.org/10.1371/journal.pcbi.1004386
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author Martens, Marijn B.
Celikel, Tansu
Tiesinga, Paul H. E.
author_facet Martens, Marijn B.
Celikel, Tansu
Tiesinga, Paul H. E.
author_sort Martens, Marijn B.
collection PubMed
description Hebbian forms of synaptic plasticity are required for the orderly development of sensory circuits in the brain and are powerful modulators of learning and memory in adulthood. During development, emergence of Hebbian plasticity leads to formation of functional circuits. By modeling the dynamics of neurotransmitter release during early postnatal cortical development we show that a developmentally regulated switch in vesicle exocytosis mode triggers associative (i.e. Hebbian) plasticity. Early in development spontaneous vesicle exocytosis (SVE), often considered as 'synaptic noise', is important for homogenization of synaptic weights and maintenance of synaptic weights in the appropriate dynamic range. Our results demonstrate that SVE has a permissive, whereas subsequent evoked vesicle exocytosis (EVE) has an instructive role in the expression of Hebbian plasticity. A timed onset for Hebbian plasticity can be achieved by switching from SVE to EVE and the balance between SVE and EVE can control the effective rate of Hebbian plasticity. We further show that this developmental switch in neurotransmitter release mode enables maturation of spike-timing dependent plasticity. A mis-timed or inadequate SVE to EVE switch may lead to malformation of brain networks thereby contributing to the etiology of neurodevelopmental disorders.
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spelling pubmed-45017992015-07-17 A Developmental Switch for Hebbian Plasticity Martens, Marijn B. Celikel, Tansu Tiesinga, Paul H. E. PLoS Comput Biol Research Article Hebbian forms of synaptic plasticity are required for the orderly development of sensory circuits in the brain and are powerful modulators of learning and memory in adulthood. During development, emergence of Hebbian plasticity leads to formation of functional circuits. By modeling the dynamics of neurotransmitter release during early postnatal cortical development we show that a developmentally regulated switch in vesicle exocytosis mode triggers associative (i.e. Hebbian) plasticity. Early in development spontaneous vesicle exocytosis (SVE), often considered as 'synaptic noise', is important for homogenization of synaptic weights and maintenance of synaptic weights in the appropriate dynamic range. Our results demonstrate that SVE has a permissive, whereas subsequent evoked vesicle exocytosis (EVE) has an instructive role in the expression of Hebbian plasticity. A timed onset for Hebbian plasticity can be achieved by switching from SVE to EVE and the balance between SVE and EVE can control the effective rate of Hebbian plasticity. We further show that this developmental switch in neurotransmitter release mode enables maturation of spike-timing dependent plasticity. A mis-timed or inadequate SVE to EVE switch may lead to malformation of brain networks thereby contributing to the etiology of neurodevelopmental disorders. Public Library of Science 2015-07-14 /pmc/articles/PMC4501799/ /pubmed/26172394 http://dx.doi.org/10.1371/journal.pcbi.1004386 Text en © 2015 Martens et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Martens, Marijn B.
Celikel, Tansu
Tiesinga, Paul H. E.
A Developmental Switch for Hebbian Plasticity
title A Developmental Switch for Hebbian Plasticity
title_full A Developmental Switch for Hebbian Plasticity
title_fullStr A Developmental Switch for Hebbian Plasticity
title_full_unstemmed A Developmental Switch for Hebbian Plasticity
title_short A Developmental Switch for Hebbian Plasticity
title_sort developmental switch for hebbian plasticity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501799/
https://www.ncbi.nlm.nih.gov/pubmed/26172394
http://dx.doi.org/10.1371/journal.pcbi.1004386
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