Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3’-Tail Sequences Are Sufficient for Tight and Complete Binding

Ends of human chromosomes consist of the six nucleotide repeat d[pTTAGGG](n) known as telomeric DNA, which protects chromosomes. We have previously shown that the DHX36 gene product, G4 Resolvase 1 (G4R1), binds parallel G-quadruplex (G4) DNA with an unusually tight apparent K(d). Recent work associ...

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Detalles Bibliográficos
Autores principales: Smaldino, Philip J., Routh, Eric D., Kim, Jung H., Giri, Banabihari, Creacy, Steven D., Hantgan, Roy R., Akman, Steven A., Vaughn, James P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501837/
https://www.ncbi.nlm.nih.gov/pubmed/26172836
http://dx.doi.org/10.1371/journal.pone.0132668

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