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Impact of cholesterol on disease progression

Cholesterol-rich microdomains (also called lipid rafts), where platforms for signaling are provided and thought to be associated with microbe-induced pathogenesis and lead to cancer progression. After treatment of cells with cholesterol disrupting or usurping agents, raft-associated proteins and lip...

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Autores principales: Lin, Chun-Jung, Lai, Cheng-Kuo, Kao, Min-Chuan, Wu, Lii-Tzu, Lo, U-Ging, Lin, Li-Chiung, Chen, Yu-An, Lin, Ho, Hsieh, Jer-Tsong, Lai, Chih-Ho, Lin, Chia-Der
Formato: Online Artículo Texto
Lenguaje:English
Publicado: China Medical University 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502043/
https://www.ncbi.nlm.nih.gov/pubmed/26048694
http://dx.doi.org/10.7603/s40681-015-0007-8
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author Lin, Chun-Jung
Lai, Cheng-Kuo
Kao, Min-Chuan
Wu, Lii-Tzu
Lo, U-Ging
Lin, Li-Chiung
Chen, Yu-An
Lin, Ho
Hsieh, Jer-Tsong
Lai, Chih-Ho
Lin, Chia-Der
author_facet Lin, Chun-Jung
Lai, Cheng-Kuo
Kao, Min-Chuan
Wu, Lii-Tzu
Lo, U-Ging
Lin, Li-Chiung
Chen, Yu-An
Lin, Ho
Hsieh, Jer-Tsong
Lai, Chih-Ho
Lin, Chia-Der
author_sort Lin, Chun-Jung
collection PubMed
description Cholesterol-rich microdomains (also called lipid rafts), where platforms for signaling are provided and thought to be associated with microbe-induced pathogenesis and lead to cancer progression. After treatment of cells with cholesterol disrupting or usurping agents, raft-associated proteins and lipids can be dissociated, and this renders the cell structure nonfunctional and therefore mitigates disease severity. This review focuses on the role of cholesterol in disease progression including cancer development and infectious diseases. Understanding the molecular mechanisms of cholesterol in these diseases may provide insight into the development of novel strategies for controlling these diseases in clinical scenarios.
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spelling pubmed-45020432015-07-17 Impact of cholesterol on disease progression Lin, Chun-Jung Lai, Cheng-Kuo Kao, Min-Chuan Wu, Lii-Tzu Lo, U-Ging Lin, Li-Chiung Chen, Yu-An Lin, Ho Hsieh, Jer-Tsong Lai, Chih-Ho Lin, Chia-Der Biomedicine (Taipei) Article Cholesterol-rich microdomains (also called lipid rafts), where platforms for signaling are provided and thought to be associated with microbe-induced pathogenesis and lead to cancer progression. After treatment of cells with cholesterol disrupting or usurping agents, raft-associated proteins and lipids can be dissociated, and this renders the cell structure nonfunctional and therefore mitigates disease severity. This review focuses on the role of cholesterol in disease progression including cancer development and infectious diseases. Understanding the molecular mechanisms of cholesterol in these diseases may provide insight into the development of novel strategies for controlling these diseases in clinical scenarios. China Medical University 2015-06-01 /pmc/articles/PMC4502043/ /pubmed/26048694 http://dx.doi.org/10.7603/s40681-015-0007-8 Text en © China Medical University 2015 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided original author(s) and source are credited.
spellingShingle Article
Lin, Chun-Jung
Lai, Cheng-Kuo
Kao, Min-Chuan
Wu, Lii-Tzu
Lo, U-Ging
Lin, Li-Chiung
Chen, Yu-An
Lin, Ho
Hsieh, Jer-Tsong
Lai, Chih-Ho
Lin, Chia-Der
Impact of cholesterol on disease progression
title Impact of cholesterol on disease progression
title_full Impact of cholesterol on disease progression
title_fullStr Impact of cholesterol on disease progression
title_full_unstemmed Impact of cholesterol on disease progression
title_short Impact of cholesterol on disease progression
title_sort impact of cholesterol on disease progression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502043/
https://www.ncbi.nlm.nih.gov/pubmed/26048694
http://dx.doi.org/10.7603/s40681-015-0007-8
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