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Impact of cholesterol on disease progression
Cholesterol-rich microdomains (also called lipid rafts), where platforms for signaling are provided and thought to be associated with microbe-induced pathogenesis and lead to cancer progression. After treatment of cells with cholesterol disrupting or usurping agents, raft-associated proteins and lip...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
China Medical University
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502043/ https://www.ncbi.nlm.nih.gov/pubmed/26048694 http://dx.doi.org/10.7603/s40681-015-0007-8 |
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author | Lin, Chun-Jung Lai, Cheng-Kuo Kao, Min-Chuan Wu, Lii-Tzu Lo, U-Ging Lin, Li-Chiung Chen, Yu-An Lin, Ho Hsieh, Jer-Tsong Lai, Chih-Ho Lin, Chia-Der |
author_facet | Lin, Chun-Jung Lai, Cheng-Kuo Kao, Min-Chuan Wu, Lii-Tzu Lo, U-Ging Lin, Li-Chiung Chen, Yu-An Lin, Ho Hsieh, Jer-Tsong Lai, Chih-Ho Lin, Chia-Der |
author_sort | Lin, Chun-Jung |
collection | PubMed |
description | Cholesterol-rich microdomains (also called lipid rafts), where platforms for signaling are provided and thought to be associated with microbe-induced pathogenesis and lead to cancer progression. After treatment of cells with cholesterol disrupting or usurping agents, raft-associated proteins and lipids can be dissociated, and this renders the cell structure nonfunctional and therefore mitigates disease severity. This review focuses on the role of cholesterol in disease progression including cancer development and infectious diseases. Understanding the molecular mechanisms of cholesterol in these diseases may provide insight into the development of novel strategies for controlling these diseases in clinical scenarios. |
format | Online Article Text |
id | pubmed-4502043 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | China Medical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-45020432015-07-17 Impact of cholesterol on disease progression Lin, Chun-Jung Lai, Cheng-Kuo Kao, Min-Chuan Wu, Lii-Tzu Lo, U-Ging Lin, Li-Chiung Chen, Yu-An Lin, Ho Hsieh, Jer-Tsong Lai, Chih-Ho Lin, Chia-Der Biomedicine (Taipei) Article Cholesterol-rich microdomains (also called lipid rafts), where platforms for signaling are provided and thought to be associated with microbe-induced pathogenesis and lead to cancer progression. After treatment of cells with cholesterol disrupting or usurping agents, raft-associated proteins and lipids can be dissociated, and this renders the cell structure nonfunctional and therefore mitigates disease severity. This review focuses on the role of cholesterol in disease progression including cancer development and infectious diseases. Understanding the molecular mechanisms of cholesterol in these diseases may provide insight into the development of novel strategies for controlling these diseases in clinical scenarios. China Medical University 2015-06-01 /pmc/articles/PMC4502043/ /pubmed/26048694 http://dx.doi.org/10.7603/s40681-015-0007-8 Text en © China Medical University 2015 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided original author(s) and source are credited. |
spellingShingle | Article Lin, Chun-Jung Lai, Cheng-Kuo Kao, Min-Chuan Wu, Lii-Tzu Lo, U-Ging Lin, Li-Chiung Chen, Yu-An Lin, Ho Hsieh, Jer-Tsong Lai, Chih-Ho Lin, Chia-Der Impact of cholesterol on disease progression |
title | Impact of cholesterol on disease progression |
title_full | Impact of cholesterol on disease progression |
title_fullStr | Impact of cholesterol on disease progression |
title_full_unstemmed | Impact of cholesterol on disease progression |
title_short | Impact of cholesterol on disease progression |
title_sort | impact of cholesterol on disease progression |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502043/ https://www.ncbi.nlm.nih.gov/pubmed/26048694 http://dx.doi.org/10.7603/s40681-015-0007-8 |
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