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Long-term cost effectiveness of ticagrelor in patients with acute coronary syndromes in Thailand
OBJECTIVES: To evaluate the long-term cost-effectiveness of ticagrelor and ASA versus generic and branded clopidogrel and ASA in patients with ACS based on a Thai cost database. METHODS: A one-year decision tree and a long-term Markov model were constructed to estimate lifetime costs and quality-adj...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502070/ https://www.ncbi.nlm.nih.gov/pubmed/26208920 http://dx.doi.org/10.1186/s13561-014-0017-3 |
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author | Yamwong, Sukit Permsuwan, Unchalee Tinmanee, Sirana Sritara, Piyamitr |
author_facet | Yamwong, Sukit Permsuwan, Unchalee Tinmanee, Sirana Sritara, Piyamitr |
author_sort | Yamwong, Sukit |
collection | PubMed |
description | OBJECTIVES: To evaluate the long-term cost-effectiveness of ticagrelor and ASA versus generic and branded clopidogrel and ASA in patients with ACS based on a Thai cost database. METHODS: A one-year decision tree and a long-term Markov model were constructed to estimate lifetime costs and quality-adjusted life years (QALYs). For the first year, data from PLATO (NCT00391872) were used to estimate the rate of cardiovascular events, resource use, and QALYs. For year 2 onwards, clinical effectiveness was estimated conditional on individual health states that occurred during the first year. RESULTS: In the base-case analysis, the incremental cost-effectiveness ratio (ICER) with ticagrelor was 292,504 ($9,476) and 60,055 ($1,946) THB($)/QALY compared with generic and branded clopidogrel, respectively. The probability of ticagrelor being cost-effective was above 99% at a threshold of 160,000 THB/QALY compared with branded clopidogrel. CONCLUSIONS: This health economic analysis provides cost effectiveness data for ticagrelor compared with both generic and branded clopidogrel in Thailand. Based on this analysis, it appears that ticagrelor is an economically valuable treatment for ACS compared with branded clopidogrel within the Thai context. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13561-014-0017-3) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4502070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-45020702015-07-17 Long-term cost effectiveness of ticagrelor in patients with acute coronary syndromes in Thailand Yamwong, Sukit Permsuwan, Unchalee Tinmanee, Sirana Sritara, Piyamitr Health Econ Rev Research OBJECTIVES: To evaluate the long-term cost-effectiveness of ticagrelor and ASA versus generic and branded clopidogrel and ASA in patients with ACS based on a Thai cost database. METHODS: A one-year decision tree and a long-term Markov model were constructed to estimate lifetime costs and quality-adjusted life years (QALYs). For the first year, data from PLATO (NCT00391872) were used to estimate the rate of cardiovascular events, resource use, and QALYs. For year 2 onwards, clinical effectiveness was estimated conditional on individual health states that occurred during the first year. RESULTS: In the base-case analysis, the incremental cost-effectiveness ratio (ICER) with ticagrelor was 292,504 ($9,476) and 60,055 ($1,946) THB($)/QALY compared with generic and branded clopidogrel, respectively. The probability of ticagrelor being cost-effective was above 99% at a threshold of 160,000 THB/QALY compared with branded clopidogrel. CONCLUSIONS: This health economic analysis provides cost effectiveness data for ticagrelor compared with both generic and branded clopidogrel in Thailand. Based on this analysis, it appears that ticagrelor is an economically valuable treatment for ACS compared with branded clopidogrel within the Thai context. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13561-014-0017-3) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2014-11-14 /pmc/articles/PMC4502070/ /pubmed/26208920 http://dx.doi.org/10.1186/s13561-014-0017-3 Text en © Yamwong et al.; licensee Springer. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Research Yamwong, Sukit Permsuwan, Unchalee Tinmanee, Sirana Sritara, Piyamitr Long-term cost effectiveness of ticagrelor in patients with acute coronary syndromes in Thailand |
title | Long-term cost effectiveness of ticagrelor in patients with acute coronary syndromes in Thailand |
title_full | Long-term cost effectiveness of ticagrelor in patients with acute coronary syndromes in Thailand |
title_fullStr | Long-term cost effectiveness of ticagrelor in patients with acute coronary syndromes in Thailand |
title_full_unstemmed | Long-term cost effectiveness of ticagrelor in patients with acute coronary syndromes in Thailand |
title_short | Long-term cost effectiveness of ticagrelor in patients with acute coronary syndromes in Thailand |
title_sort | long-term cost effectiveness of ticagrelor in patients with acute coronary syndromes in thailand |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502070/ https://www.ncbi.nlm.nih.gov/pubmed/26208920 http://dx.doi.org/10.1186/s13561-014-0017-3 |
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