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Effect of Lycopene on Serum Nitrite-Nitrate Levels in Diabetic Rats
The effect of lycopene on serum nitrate-nitrite levels was investigated in diabetic rats. In this investigation, 28 Wistar rats were divided into 4 groups, each of seven rats. These groups were control group, diabetes group, diabetes-lycopene group and lycopene group. The concentration of nitrite an...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502153/ https://www.ncbi.nlm.nih.gov/pubmed/26180284 |
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author | Yegın, Sevım Ç. Yur, Fatmagül Çetın, S. Güder, A. |
author_facet | Yegın, Sevım Ç. Yur, Fatmagül Çetın, S. Güder, A. |
author_sort | Yegın, Sevım Ç. |
collection | PubMed |
description | The effect of lycopene on serum nitrate-nitrite levels was investigated in diabetic rats. In this investigation, 28 Wistar rats were divided into 4 groups, each of seven rats. These groups were control group, diabetes group, diabetes-lycopene group and lycopene group. The concentration of nitrite and nitrate was detected at high levels in diabetes group, diabetes-lycopene group and lycopene group as compared with the control group (P<0.05). Especially, the increase in the levels of nitrate in diabetes group and lycopene group was statistically significant when compared with diabetes-lycopene group and control group (P<0.05). In addition, we also determined the proportion of nitrite/nitrate for nitric oxide radical formation. Therefore, it is important to investigate the recovery and stability of nitrite and nitrate in samples. As a result of this study, it was observed that the amounts of nitrate and nitrite increased due to oxidative stress in diabetes and also application of antioxidant lycopene caused an increase in the amounts of nitrate and nitrite levels. |
format | Online Article Text |
id | pubmed-4502153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-45021532015-07-15 Effect of Lycopene on Serum Nitrite-Nitrate Levels in Diabetic Rats Yegın, Sevım Ç. Yur, Fatmagül Çetın, S. Güder, A. Indian J Pharm Sci Short Communications The effect of lycopene on serum nitrate-nitrite levels was investigated in diabetic rats. In this investigation, 28 Wistar rats were divided into 4 groups, each of seven rats. These groups were control group, diabetes group, diabetes-lycopene group and lycopene group. The concentration of nitrite and nitrate was detected at high levels in diabetes group, diabetes-lycopene group and lycopene group as compared with the control group (P<0.05). Especially, the increase in the levels of nitrate in diabetes group and lycopene group was statistically significant when compared with diabetes-lycopene group and control group (P<0.05). In addition, we also determined the proportion of nitrite/nitrate for nitric oxide radical formation. Therefore, it is important to investigate the recovery and stability of nitrite and nitrate in samples. As a result of this study, it was observed that the amounts of nitrate and nitrite increased due to oxidative stress in diabetes and also application of antioxidant lycopene caused an increase in the amounts of nitrate and nitrite levels. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4502153/ /pubmed/26180284 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Short Communications Yegın, Sevım Ç. Yur, Fatmagül Çetın, S. Güder, A. Effect of Lycopene on Serum Nitrite-Nitrate Levels in Diabetic Rats |
title | Effect of Lycopene on Serum Nitrite-Nitrate Levels in Diabetic Rats |
title_full | Effect of Lycopene on Serum Nitrite-Nitrate Levels in Diabetic Rats |
title_fullStr | Effect of Lycopene on Serum Nitrite-Nitrate Levels in Diabetic Rats |
title_full_unstemmed | Effect of Lycopene on Serum Nitrite-Nitrate Levels in Diabetic Rats |
title_short | Effect of Lycopene on Serum Nitrite-Nitrate Levels in Diabetic Rats |
title_sort | effect of lycopene on serum nitrite-nitrate levels in diabetic rats |
topic | Short Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502153/ https://www.ncbi.nlm.nih.gov/pubmed/26180284 |
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