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Diagnosing Paroxysmal Atrial Fibrillation: Are Biomarkers the Solution to This Elusive Arrhythmia?

Atrial fibrillation (AF) is the commonest sustained arrhythmia globally and results in significantly increased morbidity and mortality including a fivefold risk of stroke. Paroxysmal atrial fibrillation (PAF) constitutes approximately half of all AF cases and is thought to represent an early stage o...

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Detalles Bibliográficos
Autores principales: Howlett, P. J., Hatch, F. S., Alexeenko, V., Jabr, R. I., Leatham, E. W., Fry, C. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502272/
https://www.ncbi.nlm.nih.gov/pubmed/26229966
http://dx.doi.org/10.1155/2015/910267
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author Howlett, P. J.
Hatch, F. S.
Alexeenko, V.
Jabr, R. I.
Leatham, E. W.
Fry, C. H.
author_facet Howlett, P. J.
Hatch, F. S.
Alexeenko, V.
Jabr, R. I.
Leatham, E. W.
Fry, C. H.
author_sort Howlett, P. J.
collection PubMed
description Atrial fibrillation (AF) is the commonest sustained arrhythmia globally and results in significantly increased morbidity and mortality including a fivefold risk of stroke. Paroxysmal atrial fibrillation (PAF) constitutes approximately half of all AF cases and is thought to represent an early stage of the disease. This intermittent form of atrial arrhythmia can be a challenge to identify and as a result many affected individuals are not prescribed appropriate antithrombotic therapy and hence are at risk of stroke and thromboembolism. Despite these adverse outcomes there have been relatively few diagnostic advances in the field since the introduction of the Holter monitor in 1949. This review aims to establish the available evidence for electrophysiological, molecular, and morphological biomarkers to improve the detection of PAF with reference to the underlying mechanisms for the condition.
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spelling pubmed-45022722015-07-30 Diagnosing Paroxysmal Atrial Fibrillation: Are Biomarkers the Solution to This Elusive Arrhythmia? Howlett, P. J. Hatch, F. S. Alexeenko, V. Jabr, R. I. Leatham, E. W. Fry, C. H. Biomed Res Int Review Article Atrial fibrillation (AF) is the commonest sustained arrhythmia globally and results in significantly increased morbidity and mortality including a fivefold risk of stroke. Paroxysmal atrial fibrillation (PAF) constitutes approximately half of all AF cases and is thought to represent an early stage of the disease. This intermittent form of atrial arrhythmia can be a challenge to identify and as a result many affected individuals are not prescribed appropriate antithrombotic therapy and hence are at risk of stroke and thromboembolism. Despite these adverse outcomes there have been relatively few diagnostic advances in the field since the introduction of the Holter monitor in 1949. This review aims to establish the available evidence for electrophysiological, molecular, and morphological biomarkers to improve the detection of PAF with reference to the underlying mechanisms for the condition. Hindawi Publishing Corporation 2015 2015-07-01 /pmc/articles/PMC4502272/ /pubmed/26229966 http://dx.doi.org/10.1155/2015/910267 Text en Copyright © 2015 P. J. Howlett et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Howlett, P. J.
Hatch, F. S.
Alexeenko, V.
Jabr, R. I.
Leatham, E. W.
Fry, C. H.
Diagnosing Paroxysmal Atrial Fibrillation: Are Biomarkers the Solution to This Elusive Arrhythmia?
title Diagnosing Paroxysmal Atrial Fibrillation: Are Biomarkers the Solution to This Elusive Arrhythmia?
title_full Diagnosing Paroxysmal Atrial Fibrillation: Are Biomarkers the Solution to This Elusive Arrhythmia?
title_fullStr Diagnosing Paroxysmal Atrial Fibrillation: Are Biomarkers the Solution to This Elusive Arrhythmia?
title_full_unstemmed Diagnosing Paroxysmal Atrial Fibrillation: Are Biomarkers the Solution to This Elusive Arrhythmia?
title_short Diagnosing Paroxysmal Atrial Fibrillation: Are Biomarkers the Solution to This Elusive Arrhythmia?
title_sort diagnosing paroxysmal atrial fibrillation: are biomarkers the solution to this elusive arrhythmia?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502272/
https://www.ncbi.nlm.nih.gov/pubmed/26229966
http://dx.doi.org/10.1155/2015/910267
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