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Persistent active avoidance correlates with activity in prelimbic cortex and ventral striatum

Persistent avoidance is a prominent symptom of anxiety disorders and is often resistant to extinction-based therapies. Little is known about the circuitry mediating persistent avoidance. Using a recently described platform-mediated active avoidance task, we assessed activity in several structures wi...

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Autores principales: Bravo-Rivera, Christian, Roman-Ortiz, Ciorana, Montesinos-Cartagena, Marlian, Quirk, Gregory J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502354/
https://www.ncbi.nlm.nih.gov/pubmed/26236209
http://dx.doi.org/10.3389/fnbeh.2015.00184
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author Bravo-Rivera, Christian
Roman-Ortiz, Ciorana
Montesinos-Cartagena, Marlian
Quirk, Gregory J.
author_facet Bravo-Rivera, Christian
Roman-Ortiz, Ciorana
Montesinos-Cartagena, Marlian
Quirk, Gregory J.
author_sort Bravo-Rivera, Christian
collection PubMed
description Persistent avoidance is a prominent symptom of anxiety disorders and is often resistant to extinction-based therapies. Little is known about the circuitry mediating persistent avoidance. Using a recently described platform-mediated active avoidance task, we assessed activity in several structures with c-Fos immuno-labeling. In Task 1, rats were conditioned to avoid a tone-signaled shock by moving to a safe platform, and then were extinguished over two days. One day later, failure to retrieve extinction correlated with increased activity in the prelimbic prefrontal cortex (PL), ventral striatum (VS), and basal amygdala (BA), and decreased activity in infralimbic prefrontal cortex (IL), consistent with pharmacological inactivation studies. In Task 2, the platform was removed during extinction training and fear (suppression of bar pressing) was extinguished to criterion over 3–5 days. The platform was then returned in a post-extinction test. Under these conditions, avoidance levels were equivalent to Experiment 1 and correlated with increased activity in PL and VS, but there was no correlation with activity in IL or BA. Thus, persistent avoidance can occur independently of deficits in fear extinction and its associated structures.
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spelling pubmed-45023542015-07-31 Persistent active avoidance correlates with activity in prelimbic cortex and ventral striatum Bravo-Rivera, Christian Roman-Ortiz, Ciorana Montesinos-Cartagena, Marlian Quirk, Gregory J. Front Behav Neurosci Neuroscience Persistent avoidance is a prominent symptom of anxiety disorders and is often resistant to extinction-based therapies. Little is known about the circuitry mediating persistent avoidance. Using a recently described platform-mediated active avoidance task, we assessed activity in several structures with c-Fos immuno-labeling. In Task 1, rats were conditioned to avoid a tone-signaled shock by moving to a safe platform, and then were extinguished over two days. One day later, failure to retrieve extinction correlated with increased activity in the prelimbic prefrontal cortex (PL), ventral striatum (VS), and basal amygdala (BA), and decreased activity in infralimbic prefrontal cortex (IL), consistent with pharmacological inactivation studies. In Task 2, the platform was removed during extinction training and fear (suppression of bar pressing) was extinguished to criterion over 3–5 days. The platform was then returned in a post-extinction test. Under these conditions, avoidance levels were equivalent to Experiment 1 and correlated with increased activity in PL and VS, but there was no correlation with activity in IL or BA. Thus, persistent avoidance can occur independently of deficits in fear extinction and its associated structures. Frontiers Media S.A. 2015-07-15 /pmc/articles/PMC4502354/ /pubmed/26236209 http://dx.doi.org/10.3389/fnbeh.2015.00184 Text en Copyright © 2015 Bravo-Rivera, Roman-Ortiz, Montesinos-Cartagena and Quirk. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Bravo-Rivera, Christian
Roman-Ortiz, Ciorana
Montesinos-Cartagena, Marlian
Quirk, Gregory J.
Persistent active avoidance correlates with activity in prelimbic cortex and ventral striatum
title Persistent active avoidance correlates with activity in prelimbic cortex and ventral striatum
title_full Persistent active avoidance correlates with activity in prelimbic cortex and ventral striatum
title_fullStr Persistent active avoidance correlates with activity in prelimbic cortex and ventral striatum
title_full_unstemmed Persistent active avoidance correlates with activity in prelimbic cortex and ventral striatum
title_short Persistent active avoidance correlates with activity in prelimbic cortex and ventral striatum
title_sort persistent active avoidance correlates with activity in prelimbic cortex and ventral striatum
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502354/
https://www.ncbi.nlm.nih.gov/pubmed/26236209
http://dx.doi.org/10.3389/fnbeh.2015.00184
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