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Contemporary approaches for imaging skeletal metastasis
The skeleton is a common site of cancer metastasis. Notably high incidences of bone lesions are found for breast, prostate, and renal carcinoma. Malignant bone tumors result in significant patient morbidity. Identification of these lesions is a critical step to accurately stratify patients, guide tr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502405/ https://www.ncbi.nlm.nih.gov/pubmed/26273541 http://dx.doi.org/10.1038/boneres.2015.24 |
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author | Ulmert, David Solnes, Lilja Thorek, Daniel LJ |
author_facet | Ulmert, David Solnes, Lilja Thorek, Daniel LJ |
author_sort | Ulmert, David |
collection | PubMed |
description | The skeleton is a common site of cancer metastasis. Notably high incidences of bone lesions are found for breast, prostate, and renal carcinoma. Malignant bone tumors result in significant patient morbidity. Identification of these lesions is a critical step to accurately stratify patients, guide treatment course, monitor disease progression, and evaluate response to therapy. Diagnosis of cancer in the skeleton typically relies on indirect bone-targeted radiotracer uptake at sites of active bone remodeling. In this manuscript, we discuss established and emerging tools and techniques for detection of bone lesions, quantification of skeletal tumor burden, and current clinical challenges. |
format | Online Article Text |
id | pubmed-4502405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45024052015-08-13 Contemporary approaches for imaging skeletal metastasis Ulmert, David Solnes, Lilja Thorek, Daniel LJ Bone Res Review Article The skeleton is a common site of cancer metastasis. Notably high incidences of bone lesions are found for breast, prostate, and renal carcinoma. Malignant bone tumors result in significant patient morbidity. Identification of these lesions is a critical step to accurately stratify patients, guide treatment course, monitor disease progression, and evaluate response to therapy. Diagnosis of cancer in the skeleton typically relies on indirect bone-targeted radiotracer uptake at sites of active bone remodeling. In this manuscript, we discuss established and emerging tools and techniques for detection of bone lesions, quantification of skeletal tumor burden, and current clinical challenges. Nature Publishing Group 2015-07-14 /pmc/articles/PMC4502405/ /pubmed/26273541 http://dx.doi.org/10.1038/boneres.2015.24 Text en Copyright © 2015 Sichuan University http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Review Article Ulmert, David Solnes, Lilja Thorek, Daniel LJ Contemporary approaches for imaging skeletal metastasis |
title | Contemporary approaches for imaging skeletal metastasis |
title_full | Contemporary approaches for imaging skeletal metastasis |
title_fullStr | Contemporary approaches for imaging skeletal metastasis |
title_full_unstemmed | Contemporary approaches for imaging skeletal metastasis |
title_short | Contemporary approaches for imaging skeletal metastasis |
title_sort | contemporary approaches for imaging skeletal metastasis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502405/ https://www.ncbi.nlm.nih.gov/pubmed/26273541 http://dx.doi.org/10.1038/boneres.2015.24 |
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